2027 Future Talent Program – Drug Metabolism and Pharmacokinetics – Co-op

Job Description

The Future Talent Program features Cooperative (Co-op) education that lasts up to 6 months and will include one or more projects. These opportunities in our Research and Development Division can provide you with great development and a chance to see if we are the right company for your long-term goals.

Our Drug Metabolism and Pharmacokinetics (DMPK) group within Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) function supports the discovery and development of antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs). The successful candidate will contribute to innovative research utilizing state-of-the-art LC-HRMS technologies and computational tools to investigate drug conjugate stability, biotransformation, and catabolism through advanced mass spectrometry and data analysis approaches. This co-op position provides an opportunity to work alongside scientists supporting oncology drug discovery programs while gaining hands-on experience in drug metabolism, bioanalysis, high-resolution mass spectrometry, and scientific data interpretation.

Project Overview

The co-op will contribute to the identification and characterization of catabolites from ADCs and PDCs using LC-HRMS and computational data analysis tools. Activities will include evaluating drug conjugate stability and biotransformation, analyzing complex mass spectrometry datasets, and supporting the development of workflows that improve the efficiency and reproducibility of catabolite identification in support of oncology drug discovery programs.

Primary Responsibilities

• Perform in vitro assays to investigate ADC and PDC biotransformation and catabolism.
• Analyze LC-HRMS data to identify and characterize drug conjugate catabolites.
• Support the development of automated tools for data processing, visualization, and reporting.
• Prepare technical summaries and presentations of project findings.
• Present project outcomes at the end-of-summer intern/co-op symposium.

Required Education

Currently pursuing a Master's, or Ph.D. degree in: Analytical Chemistry, Pharmaceutical Sciences, Chemical Biology, Immunology, Biochemistry, Biotechnology, Biology, Data Science, or related scientific discipline.

Required Skills

• Experience with high resolution mass spectrometry and data analysis.
• Strong analytical, critical thinking, and problem-solving skills.
• Experience using Microsoft Excel for data analysis and visualization.
• Effective verbal and written communication skills.
• Ability to work both independently and collaboratively in a team environment.

Preferred Skills

• Familiarity with mass spectrometry data processing tools.
• Experience with Python, R, or similar analytical tools is a plus but not required.
• Familiarity with PK, ADME or drug discovery concepts.
• Familiarity with cell culture is a plus.

Learning Opportunities

The intern will gain exposure to: Advanced bioanalytical techniques, including LC-HRMS and sample preparation workflows; Drug conjugates biotransformation studies in a pharmaceutical research environment; Data analysis, interpretation, and visualization of complex biotransformation datasets; Cross-functional collaboration within a pharmaceutical research organization; Scientific communication and presentation skills.

Expected Deliverables

• Data analysis report and recommendations.
• Final presentation summarizing project objectives, methods, results, and impact.