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AI Engineer – Discovery

AstraZeneca

Cambridge, MAOnsitePosted 1 day ago$124,000 - $187,000/year
Full TimeSenior LevelBioinformatics & Data SciencePharmaceutical
Original posting ↗

Summary

We are seeking a cross-disciplinary AI Engineer to support a highly wet-lab-focused discovery research team working at the forefront of CAR-T, in vivo lentiviral delivery, and oncology. This role will help accelerate research by applying AI, machine learning, and data-centric engineering to experimental workflows, biological data, and decision-making across early discovery and platform development.

Job description

Key Responsibilities

  • Partner with experimental scientists working in CAR-T, lentiviral delivery, cell engineering, and oncology discovery to understand key scientific questions, assay workflows, and experimental decision points.
  • Translate wet-lab problems into AI and data science opportunities, such as construct prioritization, delivery optimization, cell-state characterization, image-based phenotyping, multimodal data integration, or prediction of experimental outcomes.
  • Build, adapt, and apply AI/ML models to support discovery activities, including predictive models, classification models, clustering approaches, representation learning, computer vision pipelines, or LLM-enabled knowledge workflows where appropriate.
  • Work across diverse biological datasets, such as flow cytometry, single-cell and bulk omics, imaging, functional assay readouts, vector characterization data, metadata, and experimental annotations.
  • Develop data pipelines and analytical frameworks that improve data quality, accessibility, interoperability, and reuse across experimental programs.
  • Create practical tools and visualizations that enable bench scientists to explore data, compare constructs or conditions, and make more informed decisions about what to test next.
  • Collaborate cross-functionally with biologists, immunologists, gene therapy scientists, bioinformaticians, data scientists, and software/informatics partners.
  • Evaluate and communicate model performance with attention to biological validity, robustness, interpretability, and limitations in real experimental settings.
  • Help establish best practices for reproducible, responsible, and scientifically grounded AI use in discovery research.
  • Monitor emerging methods in AI, computational biology, and multimodal learning, and identify opportunities to apply them meaningfully in CAR-T and in vivo delivery research.

Required Qualifications

  • Bachelor’s in computer science, machine learning, computational biology, bioinformatics, biomedical engineering, systems biology, applied mathematics, or a related field.
  • At least 5 years' experience developing AI/ML solutions in biological, biomedical, or R&D environments.
  • Strong programming skills in Python and experience with relevant data science and machine learning frameworks.
  • Experience working with complex experimental datasets and building practical analyses or tools that support scientific decision-making.
  • Ability to work effectively with wet-lab researchers and communicate clearly across computational and experimental disciplines.
  • Experience handling ambiguity and translating open-ended scientific questions into structured computational approaches.
  • Strong grounding in data quality, model evaluation, reproducibility, and analytical rigor.

Preferred Qualifications

  • Advanced degree preferred (Master’s, or PhD)
  • Experience in one or more of the following areas: cell therapy, CAR-T, gene therapy, viral vector biology, lentiviral systems, immuno-oncology, or functional genomics.
  • Familiarity with biological data modalities relevant to this space, including flow cytometry, single-cell RNA-seq, multimodal omics, imaging, perturbation datasets, and high-dimensional assay data.
  • Experience with multimodal learning, representation learning, scientific image analysis, active learning, Bayesian optimization, LLM-enabled scientific workflows, or knowledge graph approaches.
  • Understanding of the practical realities of discovery-stage wet-lab research, including assay variability, small and noisy datasets, metadata challenges, and iterative hypothesis testing.
  • Experience developing user-facing tools, dashboards, or decision-support applications for scientific teams.
  • Familiarity with cloud, data engineering, or production-oriented workflows for research computing environments.

Requirements

  • Bachelor’s in computer science, machine learning, computational biology, bioinformatics, biomedical engineering, systems biology, applied mathematics, or a related field
  • At least 5 years' experience developing AI/ML solutions in biological, biomedical, or R&D environments
  • Strong programming skills in Python and experience with relevant data science and machine learning frameworks
  • Experience working with complex experimental datasets and building practical analyses or tools that support scientific decision-making
  • Ability to work effectively with wet-lab researchers and communicate clearly across computational and experimental disciplines
  • Experience handling ambiguity and translating open-ended scientific questions into structured computational approaches
  • Strong grounding in data quality, model evaluation, reproducibility, and analytical rigor

Benefits

  • Retirement Programs
  • Paid Time Off
  • Vacation
  • Holiday Pay
  • Health Insurance
  • Dental Insurance
  • Vision Coverage
  • Short-Term Incentive Bonuses
  • Equity-Based Awards

Company overview

AstraZeneca is a global, science-led, patient-focused pharmaceutical company dedicated to accelerating the delivery of life-changing medicines that create enduring value for patients, society, and shareholders. With a workforce of over 94,300 employees worldwide, the company operates across three core therapy areas: Oncology, BioPharmaceuticals (including Cardiovascular, Renal & Metabolism, Respiratory & Immunology), and Rare Disease. Headquartered in Cambridge, UK, AstraZeneca maintains strategic R&D centers in Cambridge, Gaithersburg (US), Boston (US), Gothenburg (Sweden), Shanghai, and Beijing. The company generated $54.1 billion in total revenue in 2024 and invested $13.6 billion in scientific research and development. AstraZeneca's bold aspiration is to be pioneers in science, lead in disease areas, and transform patient outcomes, with a goal to launch 20 new medicines and achieve $80 billion in total revenue by 2030. The company is recognized for its commitment to sustainability, health equity, and creating an inclusive work environment where diverse perspectives drive innovation.

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