Analytical Scientist I
Prolific Machines
Summary
The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to quantify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein quantification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting a wide range of protein quality assessments.
Job description
Key Responsibilities
- Collaborate with cell line development and bioprocess teams for delivery of key internal technology programs and external customer projects.
- Develop, optimize, and validate assays for protein titer and quality for broad classes of recombinant therapeutic proteins.
- Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
- Execute, summarize, interpret, and present routine and complex therapeutic protein characterizations.
- Qualify and validate analytical procedures to compliance standards, upholding rigorous standards for execution and documentation.
- Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
- Author, review, and implement methods, protocols, validations, and standard operating procedures. Ensure processes are followed in accordance with these standards.
About You
- Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
- Have illustrated experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
- Have illustrated the ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
- Have illustrated the ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
- Have experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
- Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.
- Are highly motivated to deliver successful outcomes for internal and external clients.
- Are excited to work with internal and external clients to deliver project excellence.
- Have strong communication skills and are comfortable teaching and sharing knowledge at multiple levels of technical detail.
Requirements
- PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience
- Experience in therapeutic protein characterization approaches (HPLC, SDS, CE, cIEF, LC-MS)
- Ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (glycosylation, disulfide mapping, peptide mapping) through mass spectrometry
- Ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics
- Experience in development and execution of GLP-compliant methods characterizing protein quality attributes
- Hands-on experience operating LC-MS
- Strong communication skills and ability to teach and share knowledge
Benefits
- Equity package
- Retirement plan
- Flexible PTO
- Medical, Dental & Vision
- Life insurance
- Disability insurance
- Career coaching
- Mental health support
- Free team lunches
- Snacks
- Companywide social events
Company overview
Prolific Machines is an innovative biotechnology company focused on developing advanced research technologies and solutions in the life sciences sector. The company specializes in creating cutting-edge tools and platforms that enhance biological research capabilities, particularly in areas requiring sophisticated automation and data analysis. As a biotechnology research firm, Prolific Machines is dedicated to advancing scientific discovery through the development of novel methodologies and instrumentation that streamline complex laboratory processes. Their work contributes to accelerating research timelines and improving experimental outcomes across various biological disciplines. The company operates at the intersection of biotechnology and engineering, leveraging interdisciplinary approaches to address challenges in modern biological research. While specific details about their product portfolio and team size are not readily available, the company's name suggests a focus on productivity and efficiency in biological research systems.