Assoc Scientist, Drug Product Development and Technology (DPDT)
Regeneron Pharmaceuticals
Summary
At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking an Associate Scientist to join our Drug Product Development & Technology group, supporting all stages of pre-clinical, clinical, and commercial formulation and drug product development for various drug product modalities. In this role, you will apply biochemical and biophysical methods to carry out developability assessment and formulation development studies on a variety of drug modalities which may include mAb, ADC, siRNA, AAV, and LNP, to support drug substance and drug product development.
Job description
When & where
- Shift Requirements: Full-time
- Location: On-site in Tarrytown, NY
What you'll do
- Execute phase-appropriate formulation development studies, such as formulation screening, stability, and compatibility studies, to support drug product development for early- and late-stage development programs
- Conduct pre-formulation studies for monoclonal antibodies, bioconjugates, and peptides, using various biophysical and biochemical techniques to identify critical quality attributes for formulation and drug product development
- Characterize drug product formulation to support process development and manufacturing of clinical drug substances and drug products
- Document findings and lab records in electronic laboratory notebook, following organizational best practices and policies
- Contribute to formulation development technical reports to provide insights into process development and manufacturing of clinical drug substances and drug products
- Participate in meetings and present study results in cross-functional team meetings or department meetings
- Author protocols and technical documents for internal use, and support regulatory filings
- Take part in general laboratory and instrument maintenance
The environment and physical rhythms of this role
- This is a laboratory environment requiring the ability to execute experiments, as well as interpret, document, and communicate results
- Strong ability to prioritize and manage multiple tasks effectively, while remaining highly organized, detail-oriented, self-motivated, and an effective team player, is required
Must-haves
- B.S. or M.S. degree in Pharmaceutical Sciences, Chemistry, Biochemistry, Biophysics, Biomedical Engineering, Analytical Chemistry, Chemical Engineering, or a related discipline, with 0-3 years of industrial experience
- Ability to execute experiments, as well as interpret, document, and communicate results
- Ability to take direction and guidance for data-driven decision making, priority setting, and technical problem solving
- Ability to generate and organize data figures and data tables in a clear and insightful way
- Excellent oral and written communication skills
Preferred / nice-to-haves
- Strong technical knowledge base and relevant experience with protein/peptide chemistry, biophysical/biochemical characterization of proteins, bioanalytical method development, and biomolecule product development
- Hands-on experience with biochemical and biophysical techniques for protein characterization, including chromatography (SEC, IEX, RP), viscosity, gel electrophoresis (CE-SDS, MCE, cIEF, iCE), particle size (DLS, HIAC, MFI), spectroscopy (UV-Vis, CD, AUC, fluorescence), and thermostability characterization (DSC, DSF)
Requirements
- B.S. or M.S. degree in Pharmaceutical Sciences, Chemistry, Biochemistry, Biophysics, Biomedical Engineering, Analytical Chemistry, Chemical Engineering, or a related discipline
- 0-3 years of industrial experience
- Ability to execute experiments, as well as interpret, document, and communicate results
- Ability to take direction and guidance for data-driven decision making, priority setting, and technical problem solving
- Ability to generate and organize data figures and data tables in a clear and insightful way
- Excellent oral and written communication skills
- Strong ability to prioritize and manage multiple tasks effectively
- Highly organized, detail-oriented, self-motivated, and an effective team player
Benefits
- Student Loan Paydown Program
- Tuition Reimbursement
- Family Care Benefits
- Relocation Assistance
- Inclusion, Culture and Well-Being Programs
- Annual Bonuses
- Equity Awards
- Pension or Retirement Benefits
- 401(k) Company Match
- Health and Wellness Programs
- Fitness Centers
- Insurance Benefits
- Paid Time Off
Company overview
Regeneron Pharmaceuticals is a leading American biotechnology company founded in 1988 and headquartered in Tarrytown, New York. The company specializes in inventing, developing, and commercializing life-transforming medicines for people with serious diseases. Regeneron is renowned for its innovative antibody technologies and has developed several groundbreaking therapies, including EYLEA® for retinal diseases, DUPIXENT® for inflammatory conditions, and the COVID-19 antibody cocktail REGEN-COV®. The company operates with a strong focus on research and development across multiple therapeutic areas including ophthalmology, oncology, cardiovascular diseases, and rare genetic disorders. Regeneron's proprietary VelocImmune® technology platform enables the rapid generation of fully human monoclonal antibodies. With over 15,000 employees globally and annual revenues exceeding $14 billion, Regeneron has established itself as a major force in the biotechnology industry, consistently ranking among the top-performing pharmaceutical companies and maintaining a robust pipeline of investigational therapies.