Associate Director/Director, Molecular Diagnostics
New York Genome Center
Summary
The Associate Director/Director will be responsible for analysis, interpretation, and reporting of molecular diagnostic tests and screening results such as genome sequencing for Constitutional Genomics, carrier screening, or Oncology assays including MRD. This individual will contribute significantly to new clinical research and assay development and to improving the existing infrastructure of variant filtering and prioritization for clinical reporting.
Job description
Job Responsibilities
- Identify, annotate and investigate the clinical significance of genetic variants found in NGS-based molecular assays for undiagnosed genetic diseases, or carrier screening, or tumor sequencing.
- Interpret and sign out reports for clinical genome sequencing from various research and clinical projects.
- Work closely with the Senior Director/lab leadership to develop and validate new NGS based tests and other translational research projects.
- Assist in creation of an efficient and scalable infrastructure for a high-volume clinical testing laboratory.
- Co-lead efforts to integrate genome sequencing into medical practice.
- Mentor junior team members.
- Responsible for creation and dissemination of precision medicine knowledge of variant-disease associations in the context of genetic disorders.
- Responsible for improving the existing infrastructure of variant filtering and prioritization used for clinical reporting.
- Participate in educational activities in the Clinical Laboratory.
- Communicate effectively and be able to explain the test results to the ordering provider and recommend additional testing.
Position Requirements
- PhD or MD in biology, genetics, biochemistry, or a related field.
- ABMGG Board certified in Clinical Molecular Genetics and Genomics, or Laboratory Genetics and Genomics, or Board certified in Molecular Genomic Pathology.
- The position may be filled at the Associate Director or Director level, depending on the candidate’s post-board-certification experience directly related to the responsibilities of the role.
- At least 4 years of post-board-certification experience in the interpretation and reporting of Exome or Genome Sequencing data and/or large-scale carrier screening is preferred for candidates at the Associate Director level, and at least 6 years of post-board-certification experience in these areas is preferred for candidates at the Director level.
- Prior experience working in a high-volume molecular diagnostic/clinical laboratory.
- Proven track record of hands-on experience in Exome/Genome Sequencing.
- Experience establishing, validating, and/or analyzing large-scale carrier screening programs is preferred.
- Experience with oncology molecular testing, including minimal residual disease (MRD) testing, is preferred.
- New York State Certificate of Qualification in genetic testing or Oncology Molecular and Cellular Tumor Markers required.
- ABMGG Board certified required.
- Thrives in a fast-paced, rapidly changing, start-up like environment.
- Experience with genetic variant classification as per ACMG/GlinGen guidelines and/or somatic variant classification as per AMP guidelines; Knowledge of phenotype ontologies.
- Self-motivated and capable of analyzing and solving complex problems through innovative thought and experience.
- Excellent verbal and written communication skills and organizational skills are essential for this role.
Requirements
- PhD or MD in biology, genetics, biochemistry, or a related field.
- ABMGG Board certified in Clinical Molecular Genetics and Genomics, or Laboratory Genetics and Genomics, or Board certified in Molecular Genomic Pathology.
- At least 4 years of post-board-certification experience in the interpretation and reporting of Exome or Genome Sequencing data and/or large-scale carrier screening is preferred for candidates at the Associate Director level, and at least 6 years of post-board-certification experience in these areas is preferred for candidates at the Director level.
- Prior experience working in a high-volume molecular diagnostic/clinical laboratory.
- Proven track record of hands-on experience in Exome/Genome Sequencing.
- Experience establishing, validating, and/or analyzing large-scale carrier screening programs is preferred.
- Experience with oncology molecular testing, including minimal residual disease (MRD) testing, is preferred.
- New York State Certificate of Qualification in genetic testing or Oncology Molecular and Cellular Tumor Markers required.
- ABMGG Board certified required.
- Thrives in a fast-paced, rapidly changing, start-up like environment.
- Experience with genetic variant classification as per ACMG/GlinGen guidelines and/or somatic variant classification as per AMP guidelines; Knowledge of phenotype ontologies.
- Self-motivated and capable of analyzing and solving complex problems through innovative thought and experience.
- Excellent verbal and written communication skills and organizational skills are essential for this role.
Benefits
- Medical, Dental & Vision
- Vacation, Holidays, Sick Leave
- Paid Winter Break
- 401(k) Matching
- Life Insurance
- Flexible Spending Accounts
- Tuition Reimbursement
- Employee Assistance Program
Company overview
The New York Genome Center (NYGC) is an independent 501(c)(3) nonprofit academic research institution established in 2011 and located in New York City. As a multi-institutional collaborative hub, NYGC focuses on advancing genomic science and its application to drive novel biomedical discoveries. The center specializes in whole genome sequencing, genomic analysis, and the development of genomic tools, serving as a nexus for collaboration in genomic research for the New York community and beyond. NYGC's research areas include understanding the genetic basis of cancer, neurodegenerative diseases, and neuropsychiatric disorders, with recent expansion into COVID-19 genomics research. The facility features state-of-the-art sequencing capabilities with 30,000 square feet of lab space housing multiple Illumina sequencing machines capable of processing over 60 whole human genomes per day. With 20 member institutions including leading academic and medical centers, NYGC operates as a collaborative research center that combines computational biology, bioinformatics, and experimental genomics to advance precision medicine and translational research.