Associate Director - QSP Quantitative Systems Pharmacology
Sanofi
Summary
At Sanofi, modeling and simulation approaches support strategy and critical decision making throughout the various phases of drug development. The Disease Modeling (DM) group is seeking a highly talented Quantitative Systems Pharmacology (QSP) modeling scientist to support its R&D portfolio. The successful candidate will independently lead QSP modeling efforts, integrate diverse biological and clinical data, and translate model insights into actionable recommendations for project teams.
Job description
Main responsibilities
- Interface with project team in aligning M&S needs and develop QSP strategy to address needs.
- Develop, and implement innovative mechanistic modeling strategies to support project team M&S needs.
- Communicate modeling predictions to key stakeholders to inform strategy and decision-making.
- Identify and interpret preclinical and clinical data critical for model development and refinement.
- Stay current with advances in systems pharmacology, disease modeling, and regulatory expectations for model-informed drug development.
- Contribute to abstracts and manuscripts.
- Perform job duties independently with minimal supervision, and mentor others to develop similar capabilities.
About You
- Ph.D. in Biomedical Engineering, Applied mathematics, Systems Biology/Pharmacology or related fields.
- ≥6 years of hands-on QSP modeling experience in the pharmaceutical or biotechnology industry, with demonstrated impact on R&D programs.
- Track record of productivity, with evidence of independence in leading scientific projects.
- Strong publication record in QSP modeling commensurate with experience.
- Hands-on experience with programming languages like Matlab/R/Julia (Matlab preferred).
- Demonstrated experience creating and using QSP models to directly influence go/no-go decisions, and competitive differentiation within pharma setting.
- Deep understanding of disease biology within at least one therapeutic area and experience applying QSP across multiple programs or drug modalities.
- Experience working with heterogeneous datasets, including preclinical, and clinical data.
- Experience with best practices for reproducible, well-documented modeling workflows.
- Proven ability to lead modeling workstreams.
- Proven ability clearly communicate quantitative insights to scientific and non-scientific stakeholders, tailoring complexity to the audience.
Preferred Experience
- Experience mentoring junior scientists.
- Understanding of neurology, neuroinflammation and neurodegeneration.
- Exposure to regulatory interactions or documentation involving MIDD.
Requirements
- Ph.D. in Biomedical Engineering, Applied mathematics, Systems Biology/Pharmacology or related fields.
- ≥6 years of hands-on QSP modeling experience in the pharmaceutical or biotechnology industry, with demonstrated impact on R&D programs.
- Track record of productivity, with evidence of independence in leading scientific projects.
- Strong publication record in QSP modeling commensurate with experience.
- Hands-on experience with programming languages like Matlab/R/Julia (Matlab preferred).
- Demonstrated experience creating and using QSP models to directly influence go/no-go decisions, and competitive differentiation within pharma setting.
- Deep understanding of disease biology within at least one therapeutic area and experience applying QSP across multiple programs or drug modalities.
- Experience working with heterogeneous datasets, including preclinical, and clinical data.
- Experience with best practices for reproducible, well-documented modeling workflows.
- Proven ability to lead modeling workstreams.
- Proven ability clearly communicate quantitative insights to scientific and non-scientific stakeholders, tailoring complexity to the audience.
Benefits
- Health insurance
- Prevention and wellness programs
- Gender-neutral parental leave
- Retirement benefits
Company overview
Sanofi is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Founded in 1973, the company has grown through strategic mergers and acquisitions to become one of the world's leading pharmaceutical corporations. Sanofi operates as an R&D-driven, AI-powered biopharma company committed to improving people's lives through breakthrough science. The company's portfolio spans seven major therapeutic areas including cardiovascular diseases, diabetes, oncology, immunology, rare diseases, neurology, and vaccines. Through its subsidiary Sanofi Pasteur, it is the world's largest producer of vaccines. Sanofi employs over 84,000 people across more than 100 countries and maintains a significant presence in both developed and emerging markets. The company's innovative pipeline focuses on advancing precision medicines and biologics while maintaining a strong commitment to sustainability and ethical business practices. Sanofi's mission centers on chasing the miracles of science to deliver transformative healthcare solutions globally.