Associate Director, Quantitative Pharmacology & Pharmacometrics - Mechanistic Modeling, Immunology
MSD
Summary
The Associate Director is an expert mechanistic modeler and a quantitative drug developer who independently designs and executes model analysis plans with minimal supervision informing translational and drug development research questions within immunology. The ideal candidate is collaborative, possesses a learning mindset and effectively partners with functional departments and external vendors to develop aligned strategies and deliver solutions.
Job description
As an Associate Director, you will participate in cross-functional teams of experienced scientists to discover and advance the clinical development of novel therapeutic agents for immunologic disorders. You will apply your expertise to frame critical drug development questions to optimize drug development using model-based approaches and influence cross-functional teams to adopt such strategies.
You will apply your quantitative skills to integrate preclinical and clinical data developing and using PK/PD, PBPK, QSP, or other mechanistic models of drug disposition and drug action to define success criteria and make model-informed decisions. Moreover, you develop and implement translational PK/PD strategies, perform clinical trial simulations, conduct comparator modeling and other model-based analyses to inform dose selection and schedule, clinical trial design and go/no-go decisions.
Requirements
- Ph.D. or equivalent degree with at least 4 years of relevant experience
- PharmD or equivalent degree with at least 6 years of relevant experience
- MS or equivalent degree with at least 8 years of relevant experience
- Relevant experience should reflect increasing responsibility and independence in pharmaceutical drug development, a regulatory agency, or academia
- Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, or chemical/biomedical engineering
- Experience in performing hands-on (population) PK / PKPD / QSP modeling using standard pharmacometric software (e.g. Phoenix, R, Matlab, NONMEM, Monolix)
- Advanced skills in experimental design, mathematical problem solving, critical thinking about data analysis and interpretation
- Proficiency in written and verbal communication and interdisciplinary collaboration
Benefits
- Medical, Dental & Vision
- Retirement benefits
- 401(k)
- Paid holidays
- Vacation
- Compassionate and sick days
- Annual bonus
- Long-term incentive
Company overview
MSD, known as Merck Sharp & Dohme outside the United States and Canada, is a global research-intensive biopharmaceutical company headquartered in Rahway, New Jersey. Founded in 1891, the company has established itself as one of the world's leading pharmaceutical corporations with a rich history spanning over 130 years. MSD operates as the international division of Merck & Co., Inc., focusing on the discovery, development, manufacturing, and marketing of innovative medicines, vaccines, biologic therapies, and animal health products. The company's extensive portfolio includes groundbreaking treatments in oncology, infectious diseases, cardiology, diabetes, and vaccines, with notable products such as Keytruda (pembrolizumab) for cancer immunotherapy, Gardasil for HPV prevention, and Januvia for diabetes management. MSD maintains a strong commitment to research and development, investing significantly in scientific innovation to address unmet medical needs worldwide. With approximately 75,000 employees globally, the company operates through four main segments: pharmaceuticals, animal health, healthcare services, and strategic alliances. MSD's mission centers on using leading-edge science to save and improve lives around the world, guided by the principle that medicine is for people, not profits.