Associate Manufacturing Scientist I
Arrowhead Pharmaceuticals
Summary
This position will involve assisting in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.
Job description
The Position
This position will involve assisting in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.
Responsibilities
- Follow batch records, SOPs, and work instructions to detail
- Document all operations in batch records and logbooks
- Comply with GMP protocols
- Operate large scale oligonucleotide manufacturing equipment (i.e. oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps, etc.)
- Assist other chemists within the Manufacturing group during synthesis and purification of oligonucleotides including reagent solution preparation, mobile phase preparation, column packing, and fraction collection
- Perform oligonucleotide/intermediate analysis via LCMS
- Communicate with cross-functional groups such as Process Development, Analytical Development, Quality Control, Quality Assurance, etc.
- Maintain a clean work space
- Maintain safety by wearing required personal protective equipment
- Track and update raw material usage in D365 ERP software
- Act as production campaign lead
- Assist with new personnel training
Requirements
- Bachelor's degree in a scientific field OR appropriate work experience
- Entry level to 2 years experience in a similar position
- Good verbal and written communication skills
- Ability to work in a team environment
- Ability to pay attention to detail
Preferred
Experience working in a GMP setting and controlled documentation
Requirements
- Bachelor's degree in a scientific field OR appropriate work experience
- Entry level to 2 years experience in a similar position
- Good verbal and written communication skills
- Ability to work in a team environment
- Ability to pay attention to detail
- Experience working in a GMP setting and controlled documentation
Benefits
- Competitive salaries
- Excellent benefit package
Company overview
Arrowhead Pharmaceuticals, Inc. is a publicly traded biotechnology company headquartered in Pasadena, California, specializing in the development of gene silencing therapeutics through RNA interference (RNAi) technology. Founded in 2004 and listed on Nasdaq under the ticker ARWR, the company focuses on treating intractable diseases by silencing disease-causing genes. Arrowhead's innovative TRiM (Targeted RNAi Molecule) platform enables precise targeting of specific messenger RNAs to reduce production of proteins associated with various conditions. The company's pipeline includes treatments for hepatitis B, liver diseases associated with alpha 1-antitrypsin deficiency, cardiovascular diseases, hypertriglyceridemia, and other metabolic disorders. With approximately 609 employees, Arrowhead has established significant partnerships with major pharmaceutical companies including Janssen, Amgen, and Takeda, demonstrating the commercial potential of its RNAi platform. The company recently achieved FDA approval for its therapy targeting Familial Chylomicronemia Syndrome (FCS), marking a significant milestone in its mission to revolutionize treatment approaches for challenging diseases.