Associate Scientist I-II, Molecular Biology & Sequencing
Mosaic Biosciences
Summary
Mosaic is seeking a highly motivated Associate Scientist I-II to join our Antibody Discovery & Optimization team, supporting our rapidly growing sequencing and molecular biology capabilities. This is an excellent opportunity for an early-career scientist with hands-on molecular biology experience who enjoys working in a fast-paced, high-throughput laboratory environment.
Job description
Primary Responsibilities
- Perform routine molecular biology techniques including PCR, DNA purification, library preparation, cloning, and nucleic acid quantification from a variety of sample types (phage, bacteria, yeast, mammalian).
- Execute high-throughput sample preparation workflows to support Sanger, Illumina, and long-read sequencing platforms.
- Carefully track samples throughout complex workflows while maintaining exceptional organization and documentation.
- Prepare reagents, master mixes, and consumables to support daily laboratory operations.
- Analyze routine quality control data and identify potential issues before downstream processing.
- Maintain accurate laboratory records using electronic laboratory notebooks (ELNs) and laboratory information management systems (LIMS).
- Assist with inventory management, reagent preparation, and laboratory organization.
- Contribute to continuous improvement initiatives by identifying workflow bottlenecks and implementing process improvements.
- Collaborate closely with scientists across sequencing, antibody discovery, and protein engineering teams to ensure timely project execution.
- Follow established laboratory procedures, quality standards, and project timelines while maintaining a strong commitment to scientific excellence.
Qualifications
- B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, Genetics, or a related life sciences discipline.
- Associate Scientist I: Bachelor's degree with 0–2 years of relevant laboratory experience (including academic research, internships, or industry experience).
- Associate Scientist II: Bachelor's degree with 2+ years of relevant industry experience or a Master's degree with relevant laboratory experience.
- Hands-on experience with common molecular biology techniques, including PCR, qPCR and DNA purification.
- Strong organizational skills with exceptional attention to detail.
- Ability to manage multiple projects while maintaining data integrity and sample traceability.
- Excellent written and verbal communication skills.
- Comfortable working in a collaborative, fast-paced environment.
Preferred Qualifications
- Experience with analysis of sequencing data (Sanger or NGS) and common analysis tools (ex: Geneious Biologics).
- Experience with automated liquid handling platforms (e.g., Opentrons, Hamilton, Tecan, Beckman, or similar).
- Familiarity with Sanger or next-generation sequencing workflows.
- Experience using ELNs, LIMS, or other laboratory data management systems.
- Exposure to antibody discovery, protein engineering, or synthetic biology workflows.
Requirements
- B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, Genetics, or a related life sciences discipline
- Associate Scientist I: Bachelor's degree with 0–2 years of relevant laboratory experience
- Associate Scientist II: Bachelor's degree with 2+ years of relevant industry experience or a Master's degree with relevant laboratory experience
- Hands-on experience with common molecular biology techniques, including PCR, qPCR and DNA purification
- Strong organizational skills with exceptional attention to detail
- Ability to manage multiple projects while maintaining data integrity and sample traceability
- Excellent written and verbal communication skills
- Comfortable working in a collaborative, fast-paced environment
Benefits
- Health insurance
- Dental insurance
- Disability insurance
- Life insurance
- 401(k) with company match
- Bonus opportunities
Company overview
Mosaic Biosciences is a Boulder, Colorado-based biotechnology company that operates as a consultative discovery partner for innovators advancing antibody and protein therapeutics. The company provides end-to-end discovery capabilities through its integrated model that combines in vivo antibody discovery, in vitro display technologies, protein engineering, bespoke assay development, and early developability analytics. Mosaic positions itself as a "Partnered Research Organization (PRO)" that works alongside biotech and pharmaceutical companies to accelerate protein therapeutic research and development programs from target validation through candidate selection. Their platform integrates exclusive access to next-generation technologies including fully human transgenic mouse platforms, proprietary phage and yeast display systems, and computational protein engineering tools. With a team of experienced drug hunters and protein engineers who have collectively advanced over 10 therapeutic candidates into clinical trials, Mosaic focuses on reducing complexity in biologic discovery by offering unified workflows that minimize handoffs and deliver predictable outcomes for their partners.