Associate Scientist II, Downstream

Position Summary

The role supports downstream process development, pilot scale execution, and technology transfer to GMP manufacturing. The position involves hands-on laboratory work, collaboration with cross-functional teams, and contribution to process development activities.

The Role

• Perform downstream processing of macromolecules expressed in mammalian cell lines, insect cells, or microbes.
• Develop and execute purification protocols from bench scale to large scale.
• Collaborate with analytical and upstream teams for purification and analysis of target molecules.
• Execute laboratory procedures and methods with high quality and moderate guidance.
• Build credibility within the group by delivering high-quality work.
• Assist other members of the Downstream Process Development group as needed.
• Follow standard operating procedures, protocols, and maintain required training.
• Manage data, complete batch and experimental records according to Good Documentation Practices (GDP).
• Document and communicate results through presentations, discussions, and meetings.
• Manage samples and inventory related to experiments.
• Assist with lab maintenance, stocking, cleaning, and troubleshooting equipment.
• Participate in project team decision-making and scientific discussions.
• Accommodate occasional weekend and evening work.
• Perform other duties as assigned.

The Candidate

Minimum Requirements

• Degree in Engineering or Life Science discipline with relevant experience (Bachelor of Arts or Bachelor of Science – at least 1+ years; or Master of Science – 0+ years).
• At least 1 year of relevant experience in biologics purification including chromatography and aseptic processing.
• Ability to sit at a desk or computer for documentation and data analysis.
• Ability to work in a laboratory environment for extended periods, including standing, walking, or sitting.
• Manual dexterity to handle laboratory instruments, pipettes, chromatography equipment, and tubing.
• Occasional lifting of containers or lab equipment up to 30 pounds.
• Good vision and hand-eye coordination for detailed work.
• Use of personal protective equipment (PPE) such as lab coats, gloves, safety goggles, and respiratory protection when required.

Preferred Skills & Background

• Experience with centrifugation, normal and tangential flow filtration, depth filtration, virus removal, and inactivation steps.
• Experience operating AKTA chromatography systems, UNICORN software, and chromatography column packing.
• Downstream process development experience specific to AAV, virus, VLP, or protein production.
• Awareness of GMP operations and process technical transfer.