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Associate Scientist or Scientist in Translational Studies in Schizophrenia Models

St. Jude Children's Research Hospital

Memphis, TNOnsitePosted 48 days ago$65,520 - $154,960/year
Full TimeSenior LevelResearch & ScientistResearch Institute
Original posting ↗

Summary

An Associate Scientist or Scientist position is available for a highly motivated individual seeking to transition from a postdoctoral role to a stable staff scientist position. The successful candidate will lead an independent research program focused on developing translational strategies to restore normal function in impaired neuronal circuits using mouse models of 22q11.2 deletion syndrome and 3q29 deletion syndrome. These rare neurodevelopmental disorders are associated with some of the highest known genetic risks for schizophrenia.

Job description

Preference will be given to applicants with Ph.D. in neuroscience or related fields, who have a strong background in molecular biology, ASO biochemistry, delivery, and validation assays, or 2-photon imaging of head-fixed animals, in vivo stereotaxic-guided injections of viruses, and strong communication skills.

The candidate also will benefit from an outstanding, highly collaborative work environment in which a diverse team of 15 researchers focuses efforts toward understanding the mechanisms of schizophrenia and psychotic behavior at the levels of neural circuits and individual neurons, synapses, and molecules.

The laboratory is part of the Department of Developmental Neurobiology, which houses specialized departmental shared resources, including an integrated support structure for testing rodent behavior, producing genetically engineered animal models and 3-dimensional human brain organoids, in vivo and ex vivo imaging of cells, advanced image processing and analysis, single-cell profiling, and bioinformatics. In addition, numerous institutional shared resources and core facilities support the laboratory by providing expertise and state-of-the-art technologies.

Job Responsibilities

  • Coordinates multiple aspects of research projects and carries out laboratory experiments utilizing various laboratory techniques, and determines whether additional or other tools or methods are required.
  • Provides input regarding research protocols and experiments. Sets up protocols and assists in developing new laboratory techniques as required.
  • Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results as required. Monitors quality and integrity of recorded information and data.
  • May draft sections of research manuscripts.
  • Provides basic lab operation support to include equipment maintenance and purchasing. Monitors inventory levels and orders lab supplies as needed. Performs calibration of instruments and equipment. Troubleshoots instrument performance and equipment issues.
  • Instructs other staff in basic laboratory techniques and procedures.
  • Maintains regular and predictable attendance.
  • Performs other related duties as assigned in order to meet the goals of the department and institution.

Minimum Education and/or Training

  • Bachelor's degree in relevant scientific area is required.

Associate Scientist Minimum Experience

  • 7+ years of research experience is required
  • 5+ years of research experience is required with a Master's degree
  • 2+ years of research experience is required with a PhD
  • Experience leading and supporting research experiments preferred
  • Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
  • Experience in guiding and training other laboratory personnel preferred
  • Proven performance in earlier role/comparable role

Scientist Minimum Experience

  • Eight (8) years of relevant work experience is required
  • Six (6) years of relevant work experience is required with a Master's degree
  • Three (3) years of relevant work experience is required with a PhD

Requirements

  • Bachelor's degree in relevant scientific area is required
  • Ph.D. in neuroscience or related fields preferred
  • Strong background in molecular biology, ASO biochemistry, delivery, and validation assays, or 2-photon imaging of head-fixed animals, in vivo stereotaxic-guided injections of viruses
  • Strong communication skills
  • 7+ years of research experience required (Associate Scientist)
  • 5+ years of research experience required with a Master's degree (Associate Scientist)
  • 2+ years of research experience required with a PhD (Associate Scientist)
  • 8 years of relevant work experience required (Scientist)
  • 6 years of relevant work experience required with a Master's degree (Scientist)
  • 3 years of relevant work experience required with a PhD (Scientist)
  • Experience leading and supporting research experiments preferred
  • Experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
  • Experience in guiding and training other laboratory personnel preferred

Benefits

  • Health Insurance
  • Excellent salary and benefits package

Company overview

St. Jude Children's Research Hospital is a world-renowned pediatric research and treatment institution headquartered in Memphis, Tennessee, dedicated to advancing cures for childhood cancer and other catastrophic diseases. Founded in 1962 by entertainer Danny Thomas, it stands as the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted exclusively to children. The hospital operates on a unique funding model where families never receive bills for treatment, travel, housing, or food, with costs exceeding $2 billion annually primarily supported by donations through its fundraising organization ALSAC. St. Jude treats approximately 8,600 patients each year from all 50 states and around the world, with a focus on acute lymphoblastic leukemia, brain tumors, sickle cell disease, and infectious diseases. The institution employs over 7,000 staff members and maintains eight affiliate clinics across the United States. Through its St. Jude Global initiative, the hospital shares research and treatment protocols internationally, partnering with more than 350 institutions in over 90 countries. St. Jude has been instrumental in increasing childhood cancer survival rates from 20% in 1962 to over 80% today, while maintaining a robust research program that includes gene therapy, bone marrow transplantation, and precision medicine approaches.

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