Summary

The Associate Scientist will primarily be responsible for the development and conduct of in vivo, ex vivo, as well as in vitro studies in Translational Sciences to support the advancement of Septerna's small molecule drug discovery pipeline. They will work independently and collaboratively in an inter-disciplinary setting to design and execute experiments in preclinical models to understand in vivo pharmacology, establish PK/PD relationships, and inform the efficacy of Septerna's therapeutic candidates. They will help generate and analyze functional in vitro, in vivo, and ex vivo data to determine the therapeutic mechanism of action, and rank candidates for preclinical development. They may also engage in biomarker discovery efforts by utilizing a variety of in vitro, in vivo and ex vivo models to enable and inform effective therapeutic development. This role is expected to be primarily in the lab with some desk work.

Job description

The Role

The Associate Scientist will primarily be responsible for the development and conduct of in vivo, ex vivo, as well as in vitro studies in Translational Sciences to support the advancement of Septerna's small molecule drug discovery pipeline. They will work independently and collaboratively in an inter-disciplinary setting to design and execute experiments in preclinical models to understand in vivo pharmacology, establish PK/PD relationships, and inform the efficacy of Septerna's therapeutic candidates. They will help generate and analyze functional in vitro, in vivo, and ex vivo data to determine the therapeutic mechanism of action, and rank candidates for preclinical development. They may also engage in biomarker discovery efforts by utilizing a variety of in vitro, in vivo and ex vivo models to enable and inform effective therapeutic development. This role is expected to be primarily in the lab with some desk work.

Key Responsibilities

Design and execute in vivo pharmacology studies to understand therapeutic mechanism in relevant disease models
Generate, analyze, document, and help interpret data to establish functional PK/PD relationships
Work collaboratively to determine the mechanism of action of drug candidates in in vivo, in vitro and ex vivo models
Be a member of multiple project teams and present results in lab, team and department meetings
Perform literature searches, read and interpret papers to help design and trouble-shoot in vivo and in vitro experiments
Help in authoring in vivo pharmacology study designs, protocols, and reports to support regulatory filings
Follow all company policies/practices, and maintain accurate records and notebooks

Requirements

BSc or MSc in Pharmacology, Toxicology, or related biological science
At least 4 years (or 2 years with MSc) direct full-time hands-on experience with in vivo studies or disease models in academia or the biotechnology and pharmaceutical industries
Demonstrated ability to be hands on and work directly with rodent models (mice and rats), including multiple routes of administration (e.g. oral, subcutaneous, intraperitoneal, intravenous, intramuscular) and sample collection (e.g. submandibular bleed, tail vein bleed, cardiac puncture, etc)
Experience working with other scientists to analyze, interpret, and present data
Ability to collaborate in writing protocols and trouble-shooting biological experiments
Detail-oriented and organized, with strong interpersonal skills for clear and effective communication
Ability to proactively engage and collaborate with colleagues

Benefits

Health Insurance
Stock Options
Annual Target Bonus

Company overview

Septerna is an innovative biotechnology company specializing in the discovery and development of novel therapeutics targeting G-protein coupled receptors (GPCRs). Founded by scientific leaders in the GPCR field, the company leverages proprietary Native Complex™ platform technology to unlock previously inaccessible GPCR targets. Septerna's approach enables the identification of small molecule drugs for historically challenging GPCRs, which represent one of the largest and most important classes of drug targets in human biology. The company focuses on developing treatments for a wide range of diseases including metabolic disorders, endocrine conditions, and other therapeutic areas where GPCR modulation can provide significant clinical benefits. With its cutting-edge technology platform and experienced team, Septerna aims to advance a pipeline of first-in-class and best-in-class therapeutics that address unmet medical needs through novel mechanisms of action.