Associate Scientist, Upstream MSAT

About the Job

Sanofi’s Global MSAT (Manufacturing Sciences, Analytics, and Technology) acts as a crucial link between our R&D and Manufacturing entities, playing an instrumental role in enhancing our current portfolio and delivering future launches of high-quality and innovative drugs and vaccines. The Associate Scientist position is part of the Upstream team in the Recombinant Drug Substance (DS) function within global MSAT and is based at the Mammalian Platform hub in Framingham, MA.

The successful candidate will work with a group of scientists and engineers responsible for development & characterization of next generation cell culture processes, technology transfer to a diverse network of manufacturing facilities, and support of advanced manufacturing investigations and process improvements for commercial products.

Main Responsibilities

• Work collaboratively within the Upstream group to execute and participate in the design of bench scale experiments
• Present data and results within department and project teams
• Author internal procedures and technical reports
• Contribute to project teams for technology transfer to pilot scale or commercial manufacturing
• Set-up and maintain upstream laboratory equipment, systems, and training
• Design and conduct experiments, interpret data, and present results to department and project teams
• Analyse process development and commercial manufacturing data in support of the MSAT mission; with the aim of improving process robustness, building process understanding and developing next-generation processes for monoclonal antibodies and recombinant proteins
• Contribute to technical investigations of complex deviations in manufacturing
• Contribute to establishment of best practices and technical ways of working within development and manufacturing teams
• Collaborate with other scientists/engineers across the biologics manufacturing network within Sanofi and with partnership organizations

About You

Basic Qualifications

• Bachelor's degree in chemical engineering, Biology, Biochemistry, or a similar or related field
• 0 to 5 years of hands-on experience in laboratory, pilot, or manufacturing scale for biologics products. Relevant academic experience (university projects, thesis work, or research) is valued and will be considered.

Preferred Qualifications

• Hands-on experience with cell culture, ideally in mammalian systems
• Experience in one or more areas of upstream process development: process transfer, scale-up/scale-down, validation, or continuous process verification as applied to mammalian-expressed proteins
• Experience with statistical analysis software
• Strong scientific background, technical writing, and presentation skills
• Highly motivated, with excellent attention to detail and the ability to work independently and in cross-functional, cross-site teams

Soft and Technical Skills

• Excellent scientific background, technical writing, and presentations skills
• Highly motivated individual with excellent attention to detail, having a proven ability to work independently and on cross-functional and cross-site teams
• Flexible with ability to adjust to a fast-paced, goal-oriented environment and willingness to expand and broaden skills
• Experience in one or more areas of upstream process development; process transfer, process scale-up/scale-down, validation, and continuous process verification as applied to mammalian-expressed proteins
• Experience with statistical analysis software
• Preferred experience in one of more areas applied to cell culture, e.g. medium development, PAT, cell banking, process intensification, computational modelling for biological system, or lab equipment automation