Cellular Biologist II

Responsibilities

• Primary responsibilities are to perform automated and manual cell culture and related activities. Sets direction for workflows; serves as technical authority; resolves complex deviations; drives optimization and innovation. Exercises expert judgment in designing experimental or production modifications and is responsible for high-level troubleshooting.
• Examples of cell culture activities include the handling and processing of primary materials, such as tumor tissues and blood samples, as well as the culturing of tissue-derived organoids, fibroblasts and induced pluripotent stem cells (iPSCs). Work collaboratively to perform all necessary protocols for organoid derivation, fibroblast expansion, iPSC expansion and QC, and differentiations on the robotic platform(s) or manually as required.
• Additional project-related activities include contributing to molecular, phenotypic, imaging assays, and other in vitro assays such as automated drug screenings using 3D organoid systems. Contribute to the design and optimize organoid co-culture protocols to model the tumor and tissue microenvironments.
• Related activities include the storage and withdrawal of specimens from liquid nitrogen and freezers, and the preparation of media and reagents required for daily work. You will work closely with the laboratory operations team to ensure reagents/consumables inventory is accurately and efficiently supplied.
• Plan and monitor resources needed to operate; maintain inventory control; coordinate space and field questions. You may be required to participate in the monitoring and tracking of resources/expenditures across projects.
• Documentation of results; identify problems, troubleshoot, and analyze variations observed and reported in regular testing protocols. Leads modification, refinement, and adaptation of techniques and procedures, partnering with engineers and other staff to define and implement large-scale improvements. Documentation and feedback is provided in a variety of ways including the creation and modification of SOPs, filing of tickets to software and automation teams, and leading inter- and intra-team meetings.
• Lead the exchange of information through demonstration and instruction. Other duties as assigned.

Qualifications

• Experience with human/mammalian cell culture, 3D culture systems, and iPSC culture with additional broad expertise in cell and molecular biology techniques, is required. While not required, experience with liquid handling automation is preferred.
• Demonstrated ability to develop and improve biological workflows/processes, or have contributed to the development of automation/software tools.
• Demonstrated ability in coordinating and performing multiple, concurrent assignments across highly complex workflows in multi-faceted projects.
• Ability to work in a fast-paced environment and interact with all individuals in a productive, professional, and positive manner to enhance the outcome of the goals of the research program.

Experience Required: 2 years. Experience Preferred: 3 years. Education Required: Bachelor's Degree. Education Preferred: Master's Degree.