Chemist I/II/III
Bachem AG
Summary
The role of the Chemist is to manufacture active pharmaceutical ingredients (APIs) and perform related activities within a cGMP regulated environment.
Job description
What you will do
- Install, operate and maintain equipment for manufacturing and in-process testing (HPLC/UPLC, lyophilizers, balances, reactors, HF cleavage equipment, diafiltration systems, water purification systems, ovens, washing systems, et al.)
- Perform solid phase and liquid phase synthesis, deprotect and cleave the API from the resin using chemical cocktails, containing HF, TFA, ammonium hydroxide or other chemicals
- Perform purification process via chromatography, crystallization and other techniques
- Follow approved GMP manufacture directions such as Master Batch Records, Standard Operation Procedures, Standard Test Procedures and other procedures to manufacture GMP materials, perform in-process test, package the product including other related activities
- Perform project-planning and initiate raw material order-request. Receive raw materials, coordinate with QA/QC and Material Management for material release and monitor raw material inventories
- Follow and maintain GMP Documentation System; Investigate deviations and produce reports; Initiate document change request; Assist quality control and assurance unit to maintain equipment calibration program
- Maintain/organize work areas (hood, bench, floor, wall, etc.) and other designated areas within the manufacturing facility
- Write and improve Standard Operation Procedures (SOP), Standard Test Procedures (STM), Master Batch Records (MBPR) and other related GMP documents
- Follow SOPs and approved directions to clean equipment used in GMP processes, maintain cleaning log for each equipment, assist in equipment calibration program, and dispose chemical waste generated in the manufacture
- Monitor compliance of maintenance and cleaning procedures of equipment and instruments used in GMP processes by periodically reviewing and signing off on maintenance and cleaning log for each equipment
Qualifications
- Bachelor’s degree in chemistry or related field (in lieu of degree, will consider 10+ years relevant experience)
- Experience in using general lab instrumentation (e.g. HPLC, UV Spectrometry)
- Experience in GMP manufacturing as well as basic knowledge of cGMP and FDA regulations (preferred)
- Experience in the manufacture of peptides and oligonucleotides (preferred)
- Capable of following GMP guidelines and housekeeping rules
- Excellent written and oral communication skills
- Communicate effectively and ability to function well in a team environment
- Ability to communicate in a proactive and solution-focused manner, including keeping direct supervisor aware of potential issues.
- Ability to accommodate four 10-hour shift schedules each week with start times as early as 5:00am or as late as 3:00pm (including either a Saturday or Sunday)
- Ability to work independently and manage one’s time
- Ability to effectively organize, multitask, and work in a fast-paced, deadline driven work environment
- Detail oriented with the ability to troubleshoot and resolve problems
- Basic computer knowledge, including Microsoft Word, Excel and PowerPoint
- Ability to work with hazardous materials and chemicals
Requirements
- Bachelor’s degree in chemistry or related field (in lieu of degree, will consider 10+ years relevant experience)
- Experience in using general lab instrumentation (e.g. HPLC, UV Spectrometry)
- Experience in GMP manufacturing as well as basic knowledge of cGMP and FDA regulations (preferred)
- Experience in the manufacture of peptides and oligonucleotides (preferred)
- Capable of following GMP guidelines and housekeeping rules
- Excellent written and oral communication skills
- Communicate effectively and ability to function well in a team environment
- Ability to communicate in a proactive and solution-focused manner, including keeping direct supervisor aware of potential issues.
- Ability to accommodate four 10-hour shift schedules each week with start times as early as 5:00am or as late as 3:00pm (including either a Saturday or Sunday)
- Ability to work independently and manage one’s time
- Ability to effectively organize, multitask, and work in a fast-paced, deadline driven work environment
- Detail oriented with the ability to troubleshoot and resolve problems
- Basic computer knowledge, including Microsoft Word, Excel and PowerPoint
- Ability to work with hazardous materials and chemicals
Benefits
- Annual performance bonus
- Medical, Dental & Vision
- 401(k) with employer contribution
- Paid vacation, personal and sick days
Company overview
Bachem AG is a leading Swiss biotechnology company specializing in the development and manufacturing of peptides and oligonucleotides. Founded in 1971 and headquartered in Bubendorf, Switzerland, the company has grown to become a global leader in the field with over 50 years of expertise. Bachem operates internationally with production facilities in Switzerland, the United States, and the United Kingdom, serving pharmaceutical and biotechnology companies worldwide. The company provides comprehensive services spanning from research-grade products to GMP manufacturing for clinical development and commercial applications. Bachem's product portfolio includes peptide new chemical entities (NCEs), oligonucleotide NCEs, commercial APIs, research chemicals, and diagnostic products. As a publicly traded company listed on the SIX Swiss Exchange, Bachem employs approximately 2,200 professionals globally and maintains a strong reputation for quality, innovation, and regulatory compliance in the pharmaceutical manufacturing sector.