Chief Research Officer

Position Summary

The Chief Research Officer (CRO) reports to the EVP, Head of Research & Development and Chief Medical Officer and provides enterprise leadership for Research, Clinical Operations and Clinical Supplies, Clinical Pharmacology, and Biometrics. The CRO connects early scientific work with rigorous clinical execution and high-quality evidence generation across Travere's rare disease portfolio, helps shape the long-term research agenda and pipeline strategy, assesses external innovation, and makes recommendations on scientific opportunity, development feasibility, investment, and risk.

Enterprise, Portfolio, and Organizational Leadership

• Serve as strategic advisor to the EVP, Head of R&D and CMO, CEO, and Board on research direction, development execution, evidence generation, portfolio choices, and organizational capabilities.
• Integrate scientific, clinical pharmacology, statistical, and operational perspectives into portfolio prioritization, investment decisions, development plans, lifecycle opportunities, and business development assessments.
• Lead scientific and translational due diligence for licensing, acquisitions, research collaborations, targets, and platform opportunities.
• Identify emerging science, technology, and academic collaboration opportunities that can strengthen Travere's rare kidney and metabolic disease pipeline.
• Develop leaders, succession plans, capabilities, resource plans, and budgets across the assigned functions.

Research and Translational Science

• Provide strategic direction to the Head of Research for discovery biology, genetics, target selection and validation, translational biology, nonclinical development, biomarkers and assays, and external scientific collaborations.
• Set research priorities and decision criteria that connect disease understanding and preclinical evidence to clinically meaningful hypotheses.
• Guide the transition from research to clinical development, including nonclinical evidence, biomarker strategy, pharmacology, and readiness for first-in-human evaluation.
• Build an external scientific network of investigators, academic institutions, disease experts, and partners.

Clinical Operations and Clinical Supplies

• Provide executive oversight of global clinical trial planning and delivery, from early studies through registrational and post-approval studies.
• Ensure sound operational plans for country and site selection, feasibility, enrollment, study start-up, monitoring, vendor and CRO oversight, clinical supplies, timelines, budgets, and trial closeout.
• Hold the organization accountable for trial quality, participant experience, data integrity, inspection readiness, and compliance with applicable GCP requirements.
• Anticipate execution risks and resolve cross-functional tradeoffs with Clinical Development, Safety, Regulatory, Quality, Technical Operations, and Program Management.

Clinical Pharmacology

• Lead the clinical pharmacology strategy across programs, including PK/PD, exposure-response, dose and regimen selection, pharmacometrics, drug interactions, human ADME, and pediatric extrapolation.
• Connect nonclinical DMPK and translational findings to clinical study design, quantitative decision-making, and regulatory submissions.
• Ensure robust analysis, interpretation, and communication of pharmacology data for protocols, study reports, health authority interactions, submissions, labeling, and lifecycle development.

Biometrics and Evidence Generation

• Provide leadership for biostatistics, statistical programming, and data management, preserving functional rigor and independent statistical judgment.
• Ensure statistical input into study design, endpoints, estimands, analysis plans, interim analyses, data standards, database lock, reporting, and integrated submission datasets.
• Align Biometrics with Clinical Development, Clinical Operations, Clinical Pharmacology, Regulatory, Medical Affairs, and Program Management on data quality, interpretation, decision milestones, and evidence needs.

Board and External Engagement

• Lead the development of the R&D content and discussion plan for the Board's Science & Technology Committee meetings.
• Present research and development priorities, progress, risks, and recommendations to the Executive Team and Board.
• Represent Travere with scientific and academic collaborators, key opinion leaders, patient communities, and strategic partners.
• Support investor or analyst discussions on R&D matters when requested.

Education/Experience Requirements

• Advanced degree in a relevant scientific, medical, or quantitative discipline, such as a PhD, MD, PharmD, or equivalent experience required.
• 17+ years of progressive biotechnology or pharmaceutical leadership experience, including significant rare disease experience is required.
• Substantial leadership experience in biotechnology or pharmaceuticals, including oversight of multiple research and development functions and demonstrated enterprise judgment.

Additional Skills/Experience

• Experience translating scientific opportunity into development programs and integrating research, clinical pharmacology, biometrics, and clinical trial execution in a matrix organization.
• Strong understanding of rare disease drug development, global clinical studies, regulatory evidence requirements, and the scientific and operational risks of a growing pipeline.
• Demonstrated ability to lead senior functional leaders, allocate resources, build teams, evaluate external opportunities, and communicate recommendations to executive and Board audiences.
• Scientific curiosity, sound quantitative judgment, collaborative leadership, and commitment to Travere's values.
• Operate effectively in a fast-paced, confidential, and matrixed environment with shifting priorities and compressed timelines.
• Team player and strong interpersonal and organizational skills and excellent verbal and written communication skills.
• Excellent decision-making and collaboration skills with strong attention to detail.
• Ability to travel domestically and internationally as business needs require and to perform onsite work in San Diego as required.

Total Rewards Offerings

Travere provides comprehensive total rewards offerings including premium health, financial, work-life and well-being offerings, wellness and employee support programs, life insurance, disability, retirement plans with employer match and generous paid time off. Compensation includes cash compensation (base pay and short-term incentive) and long-term incentive compensation (company stock). Target Base Pay Range: $325,000.00 - $439,000.00.