Clinical Development Director
Enveda
Summary
As a Clinical Development Director at Enveda, you won't be working on another me-too drug. You'll be working on a first-in-class opportunity with broad potential across metabolism and autoimmune disease, and it's one of the most exciting bets in our pipeline. You will own the core clinical development plan, design the first-in-human program, and build the path that turns a novel mechanism into a potentially transformational medicine in two therapeutic areas. This is a critical leadership role on the Asset team, where you will have a significant impact on its direction and success while collaborating with some of the brightest minds in the industry.
Job description
Your Role
As a Clinical Development Director at Enveda, you won't be working on another me-too drug. You'll be working on a first-in-class opportunity with broad potential across metabolism and autoimmune disease, and it's one of the most exciting bets in our pipeline. You will own the core clinical development plan, design the first-in-human program, and build the path that turns a novel mechanism into a potentially transformational medicine in two therapeutic areas. This is a critical leadership role on the Asset team, where you will have a significant impact on its direction and success while collaborating with some of the brightest minds in the industry.
What You'll Do
- Build the clinical development plan and first-in-human strategy from the ground up
- Design the Phase 1 protocol: dose, endpoints, population, pharmacodynamic readouts, and the design nuance of testing across two therapeutic areas, plus the operational realism to make it run
- Shape the translational and biomarker strategy that turns a preclinical mechanism into a credible human proof-of-mechanism readout
- Support the path to IND and the early regulatory strategy behind it
- Run Advisory Boards that produce decision-grade insight and genuinely change how we approach trial design and next steps
- Build the KOL and site network ahead of the clinic, so we're ready to move when the study opens
- Excite thought leaders, physicians, PIs, and patients about the opportunity in metabolism and autoimmune disease
- Contribute to the broader platform narrative for investors and partners where scientific credibility is on the line
What We're Looking For
- MD, with credentials that add actual and perceived credibility to the program
- Live, warm global KOL and site network in autoimmune disease (metabolic disease as well is a plus)
- Track record of taking assets into the clinic and landing non-trivial first-in-human and early-phase programs. Bonus points for at least one 'not just another X study' where design creativity was the unlock
- First-hand experience designing and running early clinical development, particularly proof-of-mechanism studies in immune-mediated disease
- Comfortable owning translational and pharmacodynamic strategy, not just trial logistics
- Clinically creative and unlocked by clinical depth; strong strategic and scientific judgement
- An undisputed champion for patients, someone willing to go to bat and change the paradigm, not just add another entry to it
- The person colleagues call when they want a straight answer; well-regarded in the community in a substantive, not just social, way
- Entrepreneurial by nature: comfortable with ambiguity, energized by building, motivated by impact over process
- Ego-lite, Enveda culture: collaborative, direct, gets the work done without needing the spotlight
We hire for trajectory, not just credentials. If you meet most of the above and care deeply about this problem, we want to hear from you.
Requirements
- MD, with credentials that add actual and perceived credibility to the program
- Live, warm global KOL and site network in autoimmune disease (metabolic disease as well is a plus)
- Track record of taking assets into the clinic and landing non-trivial first-in-human and early-phase programs
- First-hand experience designing and running early clinical development, particularly proof-of-mechanism studies in immune-mediated disease
- Comfortable owning translational and pharmacodynamic strategy, not just trial logistics
- Clinically creative and unlocked by clinical depth; strong strategic and scientific judgement
- An undisputed champion for patients, someone willing to go to bat and change the paradigm
- The person colleagues call when they want a straight answer; well-regarded in the community in a substantive, not just social, way
- Entrepreneurial by nature: comfortable with ambiguity, energized by building, motivated by impact over process
- Ego-lite, Enveda culture: collaborative, direct, gets the work done without needing the spotlight
Benefits
- Medical, Dental & Vision
- 401(k) Matching
- Flexible PTO
- Company-wide recharge break
- Adoption assistance
Company overview
Enveda is an innovative biotechnology company that leverages artificial intelligence and natural product chemistry to accelerate drug discovery. Founded in 2019 and headquartered in Boulder, Colorado with operations in Hyderabad, India, Enveda has developed a proprietary platform that reads and translates nature's hidden chemistry at unprecedented speed and scale. The company's approach focuses on identifying and characterizing molecules produced by living organisms, creating what they call 'the library of life' - a database of chemical biodiversity that represents billions of years of evolutionary intelligence. By combining AI-powered tools with metabolomics expertise, Enveda aims to discover medicines four times faster than the industry average. The company has already advanced multiple drug candidates into clinical development, including ENV-294 for atopic dermatitis, demonstrating their ability to rapidly translate natural product discoveries into therapeutic candidates. With a team of 201-500 employees and recent unicorn status achieved through a $150 million Series D funding round, Enveda represents a new generation of biotech companies integrating advanced technology with nature's evolved chemistry to address pressing medical needs.