Conjugation Scientist

Job Description Summary

We are seeking a highly motivated and exceptional chemist for a position within a Discovery Chemistry Department located at a South San Francisco, CA site. The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates.

Job Responsibilities

• Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods
• Select and apply appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography)
• Acquire and interpret analytical data such as LC/MS
• Document experimental results and present data to project teams
• Maintain training and compliance in areas of health and safety, security, environmental and operational aspects of daily activities in the working environment

Critical Skills

• Working knowledge of bioconjugation and analytical techniques such as HIC, SEC, RP chromatography, SDS-PAGE, and UV-Vis
• Strong foundation in organic chemistry and laboratory synthetic techniques
• Excellent interpersonal, collaboration, and communication skills in a team environment
• Ability to learn quickly through on-the-job training and become increasingly skilled and independent in reaction setup, route design, and optimization

Basic Qualifications

• B.S. or equivalent degree in chemistry, biochemistry, or related field, with industrial or academic experience with 2+ years of relevant work experience

Preferred Qualifications

• Hands-on experience with conjugation, purification, and characterization of antibody-drug conjugates (ADCs)
• Relevant experience applying organic synthesis to the design, preparation, and optimization of small molecules, linker-payloads, or related intermediates
• Experience independently designing, executing, and optimizing synthetic routes using modern synthetic techniques
• Knowledge of and experience interpreting biological activity data, including structure-activity relationships