Summary

The Director, Clinical Pharmacology is responsible for leading the planning, implementation, and execution of clinical pharmacology strategies across one or more development programs, reporting to the Senior Director, Clinical Pharmacology & Pharmacometrics. This role drives trial- and program-level activities, applying pharmacokinetics/pharmacodynamics (PK/PD) principles and model-informed approaches to support decision-making throughout drug development. The Director partners cross-functionally to shape and deliver integrated development strategies, contributes as a key member of Clinical Pharmacology leadership and program teams, and ensures the development and execution of robust Clinical Pharmacology & Pharmacometrics (CP&P) plans aligned with compound strategy. In addition, the role fosters a collaborative and supportive environment that promotes scientific excellence and continuous learning.

Job description

Position Summary

The Director, Clinical Pharmacology is responsible for leading the planning, implementation, and execution of clinical pharmacology strategies across one or more development programs, reporting to the Senior Director, Clinical Pharmacology & Pharmacometrics. This role drives trial- and program-level activities, applying pharmacokinetics/pharmacodynamics (PK/PD) principles and model-informed approaches to support decision-making throughout drug development. The Director partners cross-functionally to shape and deliver integrated development strategies, contributes as a key member of Clinical Pharmacology leadership and program teams, and ensures the development and execution of robust Clinical Pharmacology & Pharmacometrics (CP&P) plans aligned with compound strategy. In addition, the role fosters a collaborative and supportive environment that promotes scientific excellence and continuous learning.

Key Responsibilities

Supervise and/or mentor other CP&P leads as appropriate
Independently contribute to compound development across various development phases
Represent Clinical Pharmacology at asset teams at governance based on proficiency
Provide input to Phase 2/3 clinical study design and registrational strategy
Accountable for Clinical Pharmacology and Pharmacometrics Plan
Lead design of Clinical Pharmacology studies and manages data analysis, interpretation, and reporting
High proficiency in PK, PK/PD, and model informed drug development (MIDD) principles and analyses
Collaborate on cross-functional drug development teams, regulatory submissions, and departmental initiatives; serves as Clinical Pharmacology subject matter expert
Participate in interactions with health authorities; serve as Clinical Pharmacology subject matter expert
Lead and participate in departmental initiatives and represent CP&P on cross-functional initiatives / workstreams / taskforces
Work with Business Development teams and provide critical expertise to assess external acquisitions

Qualifications & Experience

MS, PhD or PharmD in relevant field or a PharmD with clinical pharmacology research fellowship
Approximately 7+ years' experience with demonstrated progression in Clinical Pharmacology and Pharmacometrics, including expertise in the general drug development process and in small molecule and/or biologic drug property characterization
In-depth knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
Strong written and oral communication skills necessary to report on and deliver scientific presentations
Demonstrate the ability to work in a dynamic team-oriented environment
Manage and provide mentorship and guidance to staff and CP&P function
Independently serve as the CP&P lead for one or more assets in the BMS drug development program
Demonstrated stakeholder management with strong influence/leadership
Programming experience is highly desired (e.g., NONMEM, R, and WinNonlin. SAS, Splus, etc.)
Quantitative data analysis, POP PK/PD, and data visualization skills are highly desired

Requirements

MS, PhD or PharmD in relevant field or a PharmD with clinical pharmacology research fellowship
Approximately 7+ years' experience with demonstrated progression in Clinical Pharmacology and Pharmacometrics
Expertise in the general drug development process and in small molecule and/or biologic drug property characterization
In-depth knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
Strong written and oral communication skills necessary to report on and deliver scientific presentations
Ability to work in a dynamic team-oriented environment
Manage and provide mentorship and guidance to staff and CP&P function
Independently serve as the CP&P lead for one or more assets in the BMS drug development program
Demonstrated stakeholder management with strong influence/leadership
Programming experience is highly desired (e.g., NONMEM, R, and WinNonlin, SAS, Splus, etc.)
Quantitative data analysis, POP PK/PD, and data visualization skills are highly desired

Benefits

Discretionary Cash Incentives
Stock Opportunities
Wellbeing Support
Retirement Benefits
Financial Protection Benefits
Medical, Dental & Vision
Life & Disability Insurance
Flexible Time Off
11 Paid Company Holidays
Paid Sick Leave
Paid Volunteer Days
Summer Hours Flexibility
Annual Global Shutdown

Company overview

Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.