Experienced Scientist, Proteomics

Purpose

Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis. Be part of a motivated team deploying cutting-edge mass spectrometry technologies to tackle challenges in end-to-end drug discovery and development. Work across a leading multiomics organization to provide coordinated insights across a variety of 'omics layers. This is a hands-on laboratory role, fit for a scientist who thrives at the bench and wants to grow in experimental design and scientific communication by working closely with senior scientists.

Responsibilities

• Joining a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities.
• Planning and performing wet lab proteomic activities supporting evaluation of therapeutic candidates.
• Generating samples for proteomics analysis from multiple sources (immortalized cell lines, FFPE, fresh-frozen tissue, plasma/serum, etc.).
• Maintaining multiple cell lines in both flasks and plates.
• Preparing assay plates and performing chemical treatments and perturbations.
• Applying high-efficiency proteomics sample preparation methodologies across many experiment types (global proteomic profiling, immunoprecipitation, affinity, PTM analysis).
• Operating and maintaining LC-MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, UltiMate 3000), including daily/weekly maintenance, calibration, and troubleshooting.
• Deploying automation-supported workflows for high-throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx.
• Ensuring QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation.
• Collaborating with colleagues within the proteomics group to drive proteomics experiments across the drug discovery portfolio.
• Demonstrating creativity and applying novel approaches to solving scientific problems.
• Proposing novel and practical ideas aligned with scientific strategies and demands.

Qualifications / Requirements

Education: A Master's degree with 1+ years, or a Bachelor's degree with 3+ years, of proven experience in a proteomics laboratory setting (in Analytical Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology, or a related field).

Experience and Skills

Required:

• Minimum of 2 years of experience with mammalian cell culture and treatment.
• Experience with label-free proteomics workflows and robust sample preparation techniques.
• Strong planning and organizational skills with the ability to handle several projects at a time in a fast-paced environment.
• Excellent interpersonal skills working with diverse colleagues.

Preferred:

• Experience with liquid chromatography (Thermo Vanquish Neo, EASY-nLC, UltiMate 3000, or Evosep One) and mass spectrometry (Thermo Exploris, Eclipse, Lumos, Astral, or Bruker timsTOF) instrumentation.
• Experience with data processing suites such as Proteome Discoverer, MaxQuant, DIA-NN, Spectronaut, or Skyline.