Expert Science and Technology - Gene Therapy Analytical Development - Chemistry
Novartis
Summary
As a key member of the Gene Therapy Analytical Development Chemistry (AD-Chem) team, the successful candidate will independently design, execute, interpret, and communicate complex analytical studies supporting gene therapy product development. The individual will apply scientific expertise to characterize product quality attributes, develop and optimize analytical methods, solve analytical challenges, and generate data that advances development programs. The role serves as a key technical contributor within multidisciplinary project teams and supports innovation in gene therapy analytics.
Job description
Role Purpose
As a key member of the Gene Therapy Analytical Development Chemistry (AD-Chem) team, the successful candidate will independently design, execute, interpret, and communicate complex analytical studies supporting gene therapy product development. The individual will apply scientific expertise to characterize product quality attributes, develop and optimize analytical methods, solve analytical challenges, and generate data that advances development programs. The role serves as a key technical contributor within multidisciplinary project teams and supports innovation in gene therapy analytics.
What You Will Be Doing
- Independently design, execute, analyze, and report analytical studies supporting gene therapy development programs.
- Develop, optimize, qualify, and transfer analytical methods for product characterization, process development, and stability assessment.
- Apply scientific expertise to troubleshoot analytical challenges and provide data-driven solutions.
- Perform characterization studies using chromatography (LC), capillary electrophoresis (CE), and biophysical analytical techniques.
- Contribute analytical expertise to cross-functional project teams and effectively communicate scientific findings and recommendations.
- Author and review technical reports, qualification documents, SOPs, and regulatory-supporting documentation.
- Evaluate emerging technologies and contribute to continuous improvement of analytical capabilities.
- Mentor junior scientists and foster a collaborative, innovative, and quality-focused work environment.
- Ensure compliance with GMP, data integrity requirements, and Novartis quality standards.
What You Will Bring to the Role
- Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 3+ years of relevant industry experience; OR MS with 4+ years; OR BS with 5+ years.
- Strong scientific foundation in analytical chemistry, protein chemistry, nucleic acid chemistry, or related disciplines.
- Experience with analytical characterization of biologics, viral vectors, or gene therapy products.
- Hands-on experience with one or more analytical platforms such as HPLC/UPLC, CE-SDS, icIEF, SEC-MALS, AUC, mass spectrometry, or particle characterization techniques.
- Demonstrated ability to independently design studies, analyze complex datasets, and solve technical challenges.
- Strong technical writing, communication, and presentation skills.
- Experience with analytical method qualification, transfer, validation, and GMP documentation is preferred.
- Experience supporting AAV and/or lentiviral vector development programs is preferred.
Requirements
- Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 3+ years of relevant industry experience; OR MS with 4+ years; OR BS with 5+ years.
- Strong scientific foundation in analytical chemistry, protein chemistry, nucleic acid chemistry, or related disciplines.
- Experience with analytical characterization of biologics, viral vectors, or gene therapy products.
- Hands-on experience with one or more analytical platforms such as HPLC/UPLC, CE-SDS, icIEF, SEC-MALS, AUC, mass spectrometry, or particle characterization techniques.
- Demonstrated ability to independently design studies, analyze complex datasets, and solve technical challenges.
- Strong technical writing, communication, and presentation skills.
- Experience with analytical method qualification, transfer, validation, and GMP documentation is preferred.
- Experience supporting AAV and/or lentiviral vector development programs is preferred.
Benefits
- Health insurance
- Life insurance
- Disability benefits
- 401(k) with company contribution and match
- Performance-based cash incentive
- Annual equity awards
- Vacation
- Personal days
- Holidays
Company overview
Novartis is a global pharmaceutical company headquartered in Basel, Switzerland, dedicated to reimagining medicine to improve and extend people's lives. As an innovative medicines company, Novartis focuses on developing high-value treatments that address society's greatest disease burdens through technology leadership in research and development. The company operates across five core therapeutic areas: cardiovascular, renal and metabolic diseases; immunology; neuroscience; oncology; and hematology. With a workforce of approximately 75,883 employees worldwide, Novartis reaches nearly 300 million patients across 118 countries. The company leverages advanced technology platforms including targeted protein degradation, cell therapy, gene therapy, radioligand therapy, and xRNA to develop breakthrough treatments. Novartis maintains a strong portfolio of oncology drugs and generics while continuously expanding its pipeline through strategic acquisitions and internal research. The company's commitment extends beyond drug development to ensuring global access to medical innovations through novel access approaches and patient assistance programs.