Faculty Position, Center of Excellence in Neuro-Oncology Sciences (CENOS)
St. Jude Children's Research Hospital
Summary
St. Jude Children’s Research Hospital invites applications for a research faculty position at the assistant/associate member rank (equivalent to assistant or associate professor) to join the newly established Center of Excellence in Neuro-Oncology Sciences (CENOS). CENOS aims to address foundational biological questions and drive clinically impactful discoveries to advance knowledge and enhance survival outcomes for children with malignant brain tumors. Successful applicants will join a cohort of thriving research groups who study childhood brain tumors from complementary angles.
Job description
We are seeking an investigator to lead a multidisciplinary research program focused on advancing our understanding of malignant childhood brain tumors through innovative approaches in fundamental biology, neuroscience, neuro-immunology, metabolism, data science, and related disciplines. We welcome candidates with expertise spanning mechanistic and translational research, including the development of human stem cell and organoid models to study mechanisms of tumorigenesis; application of advanced multi-omics technologies to characterize tumor, immune, and metabolic states and discover resistance mechanisms; deployment of cancer neuroscience strategies to study communication networks that promote and maintain malignancy; investigation of neuro-immune interactions and metabolic dependencies that influence tumor initiation, progression, and therapeutic response; evaluation of novel selective dependencies and the mechanisms governing these vulnerabilities; and application of machine learning, artificial intelligence, and other advanced data science methodologies to enhance biological discovery, diagnostics, and treatments for malignant childhood brain tumors. Early career investigators interested in contributing to a culture of excellence at St. Jude are encouraged to apply.
St. Jude is a highly interactive environment offering its faculty a remarkable opportunity to perform groundbreaking independent and collaborative research. We provide long-term institutional support past start-up to facilitate innovation and discovery. St. Jude provides an impressive array of shared resources and core facilities to support research and discovery efforts across the institution relevant to pediatric cancer. This includes an extensive biorepository of clinical samples, patient derived xenografts, and genomic datasets matched to patients enrolled on St. Jude clinical trials. CENOS investigators have access to specialized departmental shared resources that include cutting edge live cell imaging, image processing & image data science, human stem cells, cell sorting and advanced animal behavior assessment. Our institutional commitment to lead in the cutting-edge imaging required for cancer neuroscience includes investments in advanced systems that include Lattice Light Sheet & MOSAIC microscopes, Helios and Teneo 3D electron microscopes, multiphoton microscopes with resonant scanning and optogenetic capabilities as well as a variety of super-resolution modalities.
We offer highly competitive packages, including substantial startup funds, equipment, laboratory space, personnel support and institutional support beyond the start-up phase. CENOS faculty reside in the Advanced Research Center, a 625,000 square foot facility designed to house cutting-edge technologies and resources to transform science and accelerate discoveries. Successful applicants may hold a Ph.D. and/or M.D. degree, have at least three years of relevant postgraduate experience, and a demonstrated track record of productivity. You will join a collaborative network of basic, translational, and clinical investigators conducting high-impact, interdisciplinary research.
Requirements
- Ph.D. and/or M.D. degree
- At least three years of relevant postgraduate experience
- Demonstrated track record of research productivity
Benefits
- Institutional support
- Startup funds
- Laboratory space
- Personnel support
- Shared resources
- Core facilities
Company overview
St. Jude Children's Research Hospital is a world-renowned pediatric research and treatment institution headquartered in Memphis, Tennessee, dedicated to advancing cures for childhood cancer and other catastrophic diseases. Founded in 1962 by entertainer Danny Thomas, it stands as the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted exclusively to children. The hospital operates on a unique funding model where families never receive bills for treatment, travel, housing, or food, with costs exceeding $2 billion annually primarily supported by donations through its fundraising organization ALSAC. St. Jude treats approximately 8,600 patients each year from all 50 states and around the world, with a focus on acute lymphoblastic leukemia, brain tumors, sickle cell disease, and infectious diseases. The institution employs over 7,000 staff members and maintains eight affiliate clinics across the United States. Through its St. Jude Global initiative, the hospital shares research and treatment protocols internationally, partnering with more than 350 institutions in over 90 countries. St. Jude has been instrumental in increasing childhood cancer survival rates from 20% in 1962 to over 80% today, while maintaining a robust research program that includes gene therapy, bone marrow transplantation, and precision medicine approaches.