Inflammation Research - In Vivo Pharmacology Scientist
Amgen
Summary
The Department of Inflammation Research is seeking a dedicated, driven and independent Senior Scientist to join the In Vivo Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs.
Job description
The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists. This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites.
Key Responsibilities
- Design, conduct and lead in vivo preclinical model studies and ex vivo analysis independently in collaboration with Inflammation scientists and collaborators.
- Design, execute and data analysis of cutting-edge research and in vivo pharmacology experiments contributing to Amgen's Inflammation TA research pipeline.
- Utilize in vivo pharmacology and animal models to validate and accelerate molecules through the research pipeline.
- Inform, collaborate, and communicate in vivo planning and results with therapeutic area (TA) scientists to align with project goals.
Basic Qualifications
- Doctorate degree OR Master's degree in immunology or cell biology, or related discipline and 2 years of industry experience in biotech/pharma OR Bachelor's degree in immunology or cell biology, or related discipline and 4 years of experience in biotech/pharma
Preferred Qualifications
- Demonstrated track record of independent critical thinking and scientific achievement as exemplified by your publication record and / or significant contribution to a therapeutic program
- Proactive, curious, and eager to learn and contribute to cutting edge science and serve patients in a highly productive team environment.
Requirements
- PhD degree in immunology, biology, pharmacology or relative disciplines
- Post-doc or industry experience will be a plus
- Strong expertise in hands-on expertise in animal (rodent) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) essential
- Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models
- Experience with colitis, lupus, arthritis, immune modulation (TLR, DTH, Immunization), and respirotoray models preferred
- Hands-on experience with ex vivo / in vitro cellular, and biochemical assay techniques (i.e. ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction) is essential
- Significant experience with multicolor flow cytometry, including Spectral flow approaches and knowledge of and experience working with immune cell populations is essential
- Experience working in a collaborative team-oriented environment and working on project teams leading in vivo contributions is essential
- Attention to detail, excellent organizational, time management, and communication skills, accurate & timely record keeping and data analysis are essential
- Demonstrated track record of independent critical thinking and scientific achievement
- Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word
Benefits
- Health insurance
- Dental coverage
- Vision coverage
- Life insurance
- Disability insurance
- Retirement and savings plan
- Flexible spending accounts
- Annual bonus program
- Stock-based long-term incentives
- Time-off plans
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.