Lab Bench Scientist - Ligand-binding assays

Your Role

EMD Serono in Billerica, MA is hiring a Senior Scientist. The New Biological Entities Drug Metabolism and Pharmacokinetics (NBE DMPK) Senior Scientist role is a scientific and operational role in Research and Development (R&D). You will collaborate in a matrixed environment with other functional experts to deliver novel biotherapeutics.

Responsibilities

• Development and fit-for-purpose validation of bioanalytical methods for sample analysis of molecules in discovery and development phases, supporting multi-specific NBEs, antibody-drug conjugates (ADCs), antibody oligonucleotide conjugates (AOCs), and other biologics from molecule design through preclinical and clinical phases.
• Use innovative immunochemical and ligand binding techniques such as ELISA, MSD-ECLA, Gyrolab, and others.
• Develop complex experimental study designs, interpret analytical data, apply knowledge of immunogenicity, and write technical reports according to company and industry standards.
• Ensure timely delivery of ligand-binding assay (LBA) bioanalytical deliverables (method development, qualification, and application to in-vivo animal studies), and conduct/supervise critical reagent characterization when needed.
• Recommend data decisions to the lab manager by providing solid results, findings, and technical solutions to project issues.
• Conduct scientific literature research to address complex technical issues and evaluate and implement potential new analytical strategies and technologies.
• Monitor bioanalytical studies at contract research organizations (CROs).

Minimum Qualifications

• PhD in Biochemistry, Biology, Chemistry, or other Science field, with 2+ years post PhD experience in developing quantitative ligand-binding assays to support PK analysis
• 2+ years of experience with biological molecules (NBEs, ADCs, AOCs, or other novel modalities)

Preferred Qualifications

• Excellent experimental design and troubleshooting skills, and excellent data analysis & data mining skills
• Experience and comfort using, optimizing, and troubleshooting the performance of laboratory instruments
• Ability to prepare bioanalytical method documentation
• Good knowledge of specific software: Watson LIMS, GraphPad Prism, Veeva Vault, etc.
• Knowledge of disease areas (e.g. Immunology, Oncology, etc.), and an understanding of biology and pharmacology
• Excellent organizational skills and both verbal and written communication skills
• Excellent inter-cultural understanding