Summary

Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools.

Job description

Description of Role

Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools.

Key Responsibilities

Clinical Supply Planning & Execution

Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable).
Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections.
Support packaging, labeling, distribution, and resupply activities for investigational products and comparators.
Ensure on-time delivery of clinical supplies to depots and clinical sites globally.

Vendor & CDMO Management

Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability.
Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites.
Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs.

Quality & Compliance Support

Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply.
Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints.
Support product recovery activities pending investigation of IP from investigator sites, as needed.

Cross-Functional Collaboration & Representation

Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes.
Author Pharmacy Manuals for clinical studies, as needed.
Represent Supply Chain in Clinical and CMC Sub-Team meetings.

Requirements

Bachelor's degree in engineering or science required
3–5 years of biotech/pharma industry experience in clinical supply chain, including international experience
Must be authorized to work in the United States on a full-time basis
Working knowledge of clinical supply chain processes and GMP/GDP requirements
Experience coordinating cross-functional project teams and external vendors
Strong organizational, analytical, decision-making, and interpersonal skills
Excellent attention to detail
Ability to work independently in a fast-paced, dynamic environment
Demonstrated ability to coordinate CDMO activities supporting clinical development of pharmaceutical products
Ability to thrive in a small-company culture and contribute to creating and implementing processes

Benefits

401(k)
Pension
Vacation benefits
Medical, Dental & Vision
Prescription drug benefits
Flexible spending accounts
Life insurance
Death benefits
Employee assistance program
Fitness benefits
Employee clubs and activities
Company bonus

Company overview

Eli Lilly and Company, commonly known as Lilly, is a leading American multinational pharmaceutical corporation headquartered in Indianapolis, Indiana. Founded in 1876 by Colonel Eli Lilly, the company has grown into one of the world's most valuable pharmaceutical enterprises, with operations in approximately 125 countries. Lilly specializes in developing and manufacturing innovative medicines across multiple therapeutic areas, including diabetes, oncology, neuroscience, immunology, and cardiometabolic diseases. The company is renowned for its groundbreaking work in insulin production, having been the first to mass-produce insulin and later developing the first commercially available insulin product in the U.S. Lilly's current portfolio includes blockbuster medications such as Mounjaro and Zepbound (tirzepatide) for diabetes and obesity, Trulicity (dulaglutide) for type 2 diabetes, Verzenio (abemaciclib) for breast cancer, and Taltz (ixekizumab) for autoimmune conditions. With approximately 47,000 employees worldwide, Lilly maintains a strong commitment to research and development, investing heavily in scientific innovation to address some of the world's most significant health challenges. The company operates with a mission to make life better for people around the world through the discovery and delivery of innovative medicines.