Post-doctoral Research Fellow - Drug Discovery, Molecular Biology, Biochemistry
Mass General Brigham
Summary
The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery.
Job description
Position Summary
The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery.
Essential Functions
- Design and perform biophysical and biochemical assays, including protein purification, binding/interaction studies, cell reporter assays, and enzymatic assays. Purify and characterize proteins for structural and functional studies.
- Design and perform protein–protein and protein–ligand interactions (e.g., SPR, ITC, pull-downs, FRET).
- Conduct cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways.
- Carry out molecular biology techniques, including cloning, mutagenesis, and protein expression. Perform mutagenesis and structure–function studies to map binding sites and mechanisms of action.
- Support hit validation and lead optimization through iterative testing of small molecules.
- Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design.
- Basic understanding of biostatistics
- Analyze and interpret experimental data, present findings in lab meetings, publications, and conferences.
- Collaborate with team members on projects linking experimental data to translational cancer research
Education and Experience
MD or PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery, small-molecule therapeutics, or translational oncology research.
Requirements
- MD or PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline)
- Strong track record of peer-reviewed publications in drug discovery, small-molecule therapeutics, or translational oncology research
- Previous research experience 3-5 years
- Demonstrated experience in research techniques, methods, or research areas relevant to the project
- Proficient analytical skills
- Proficiency in statistical software
- Excellent written and verbal communication skills
- Ability to work independently as well as collaboratively within a team
- Good interpersonal and communication skills
Company overview
Mass General Brigham is one of the largest integrated healthcare delivery systems in the United States, formed through the merger of Massachusetts General Hospital and Brigham and Women's Hospital. Based in Boston, Massachusetts, this academic medical center system operates multiple hospitals, specialty facilities, and community health centers throughout New England. The organization is renowned for its world-class patient care, cutting-edge medical research, and comprehensive medical education programs. As a teaching affiliate of Harvard Medical School, Mass General Brigham trains the next generation of healthcare professionals while advancing medical science through groundbreaking research initiatives. The system provides a full continuum of healthcare services, from primary care and preventive medicine to complex specialty treatments and emergency services. With a focus on innovation and patient-centered care, Mass General Brigham consistently ranks among the top hospital systems in the nation for clinical excellence and research output.