Post Doctoral Research Scientist - Bioinformatics (m/f/d)
Dr. Margarete Fischer-Bosch Institut für Klinische Pharmakologie
Summary
The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director: Prof. Dr. M. Schwab) is operated by the Robert Bosch Foundation. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic, epigenetic, metabolic and non-genetic factors on variability of drug efficacy and their contributions to disease development. Currently, we are looking for a Post Doctoral Research Scientist - Bioinformatics (m/f/d) for a research project investigating cancer therapy and tumor cell biology of renal cell carcinoma. The project will focus on the bioinformatic analysis of transcriptomics data, particularly spatial transcriptomics combined with single cell datasets, as well as spatial multiplex immunofluorescence data. It offers the opportunity to develop novel bioinformatics solutions. Functional studies using 3D tumour cell models complement the data sets in order to enhance our understanding of tumour biology in renal cell carcinoma. The project will be closely linked to clinical aspects of cancer research.
Job description
Job Description
- Bioinformatic analysis of multi-omics data with focus on single-cell and spatial transcriptomics RNA sequencing data to elucidate the tumor microenvironment and its influence on cancer progression and metastasis in renal cell carcinoma
- Integrating multi-omics data sets (e.g. genomics, metabolomics) of primary tumors and metastasis through innovative bioinformatics analysis applicable to high-dimensional data.
- Integrated analysis of clinical phenotypes and -omics data using biostatistics and bioinformatics
- Application of a broad spectrum of established tools and development of new computational solutions with focus on single-cell and spatial transcriptomics RNA seq and data integration
- Enthusiasm to present scientific results at international conferences and writing papers for high-quality publications to ensure greatest possible success in your career track
Qualifications
- Doctoral degree (PhD) in bioinformatics, applied bioinformatics or a related discipline
- Experience and strong background in the analysis of spatial transcriptomics and single-cell RNA sequencing data, as well as multi-omics datasets (e.g. proteomics, transcriptomics, genomics), including data interpretation.
- Strong interest in life science applications with focus on oncology and personalized medicine
- Strong programming skills in R and in Python
- Solid background in cancer biology
- Knowledge in biostatistics would be beneficial
- Excellent English written and oral communication skills, as well as expertise in preparation of scientific manuscripts.
We offer
- The opportunity to work in an interactive team of bioinformaticians, clinicians and biologists.
- State-of-the-art equipment and technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities (e.g. core facility “Biostatistics/Bioinformatics, Pharmacometrics and Digital Science”) at the institute
- The opportunity to communicate scientific results at international conferences and to participate in workshops
- An initial contract for 3 years and flexible starting date (earliest starting date as of now)
Requirements
- Doctoral degree (PhD) in bioinformatics, applied bioinformatics or a related discipline
- Experience and strong background in the analysis of spatial transcriptomics and single-cell RNA sequencing data, as well as multi-omics datasets (e.g. proteomics, transcriptomics, genomics), including data interpretation.
- Strong interest in life science applications with focus on oncology and personalized medicine
- Strong programming skills in R and in Python
- Solid background in cancer biology
- Knowledge in biostatistics would be beneficial
- Excellent English written and oral communication skills, as well as expertise in preparation of scientific manuscripts.
Benefits
- Interactive Multidisciplinary Team
- State-Of-The-Art Equipment And Technologies
- Conference Participation
- Workshop Participation
Company overview
The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP) is a nonprofit research institute located at the Bosch Health Campus in Stuttgart, Germany. Founded in 1973 through a donation from Dr. Margarete Fischer-Bosch, the eldest daughter of Robert Bosch, the institute is recognized as the largest scientific research unit in the field of clinical pharmacology in Germany and enjoys a high international reputation. With more than 70 employees working across eleven research groups, the IKP focuses on personalized medicine and pharmacogenomics, investigating how genetic and non-genetic factors influence individual drug responses. Its core research areas include oncology and pharmacogenomics, combining advanced multidimensional pharmaco-omics (genomics, transcriptomics, epigenomics, metabolomics) to identify new drug targets, biomarkers, and innovative therapeutic concepts. The institute is renowned for developing the "DNA medication passport," which has been shown to reduce drug side effects by 30 percent, and for pioneering work such as the TAMENDOX project for breast cancer therapy. The IKP collaborates closely with the Robert Bosch Hospital and leading international research institutions.