Postdoctoral Fellow - Multimodal Technologies & Complex Human Models, Regev and Chen Labs
Roche
Summary
A Postdoctoral Fellow position is available for a highly motivated and independent scientist to develop novel single cell and spatial omics platforms to screen next generation complex human in vitro models in order to accelerate target discovery. The candidate will develop new experimental and computational methods to characterize cellular responses to perturbations and generate high-dimensional datasets that enable a deeper understanding of disease biology.
Job description
This is a hands-on position for a scientist passionate about assay development as well as engaging in state-of-the-art computational tools, including and especially AI. You will join a collaborative, cross-disciplinary environment and will have the opportunity to contribute to high-impact scientific publications.
The Opportunity
- Novel Assay Development: Develop scalable measurement tools to acquire molecular, imaging and functional readouts from perturbation studies in in vitro complex models
- Large-Scale Screening: Design and execute multimodal functional genomics screens to investigate mechanisms underlying disease cellular and tissue states
- Computational Methods: Collaborate with computational biologists and AI scientists to develop approaches for integrating and interpreting multimodal data, and explore predictive modeling strategies to power Lab-in-the-Loop
- Collaborative Research: Collaborate productively with experimental and computational scientists across labs and departments, present your work to project teams, and contribute to high-impact scientific publications
- Professional Development: Join Genentech's postdoctoral training program, which provides an outstanding environment and the opportunity to pursue fundamental scientific questions while building methods that drive breakthrough discoveries in drug development
Who You Are
- Ph.D. with a proven track record of excellence in single-cell genomics, spatial-omics, imaging, bioengineering, biophysics, quantitative biology, or a related field, with hands-on experimental expertise
- Must have advanced at least one key research project as evidenced by a first-author paper published or accepted in a leading peer-reviewed journal, or on Biorxiv
- Strong hands-on experience in molecular biology, functional genomics, single-cell genomics, and/or spatial-omics
- Experience with complex mammalian cell culture, with experience in iPSC-cell models, organoids or 3D cultures a plus
- Computational experience spanning single cell genomic or spatial data analysis, with a track record of programming fluently in Python or a comparable language
- Independent scientist with outstanding communication skills, a strong passion and commitment to science, who works well within a team
Requirements
- Ph.D. in single-cell genomics, spatial-omics, imaging, bioengineering, biophysics, quantitative biology, or a related field
- Proven track record of excellence with hands-on experimental expertise
- Must have advanced at least one key research project as evidenced by a first-author paper published or accepted in a leading peer-reviewed journal, or on Biorxiv
- Strong hands-on experience in molecular biology, functional genomics, single-cell genomics, and/or spatial-omics
- Experience with complex mammalian cell culture
- Experience in iPSC-cell models, organoids or 3D cultures a plus
- Computational experience spanning single cell genomic or spatial data analysis
- Track record of programming fluently in Python or a comparable language
- Independent scientist with outstanding communication skills
- Strong passion and commitment to science
- Works well within a team
Benefits
- Relocation benefits
- Professional development workshops
- Mentorship program
- Networking opportunities
- Fully funded research expenses
Company overview
Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.