Postdoctoral Fellow - RNA Genomics
Lieber Institute Inc
Summary
We are seeking a highly motivated and self-driven postdoctoral fellow to join our research group. Our research focuses on understanding how gene regulatory mechanisms are disrupted in psychiatric and neurological disorders and how these insights can be translated into novel therapeutic strategies.
Job description
Job Summary
We are seeking a highly motivated and self-driven postdoctoral fellow to join our research group. Our research focuses on understanding how gene regulatory mechanisms are disrupted in psychiatric and neurological disorders and how these insights can be translated into novel therapeutic strategies.
The successful candidate will lead the design and execution of experimental studies and collaborate closely with computational biologists to analyze and interpret experimental results.
Key Responsibilities
- Design, perform, and troubleshoot molecular biology experiments using neuronal cell culture systems.
- Prepare next-generation sequencing (NGS) libraries for genomic assays, including RNA-seq, ATAC-seq, and CUT&RUN.
- Perform molecular cloning and viral transduction.
- Conduct molecular and cellular assays, including qPCR, Western blotting, and immunohistochemistry.
- Collaborate with computational biologists to integrate experimental and computational findings.
- Other duties as assigned.
Minimum Qualifications
- Ph.D. in molecular neurobiology or a closely related field.
- Extensive experience in neuronal cell culture, including primary neurons and/or stem cell-derived neuronal models.
- Strong experimental design and troubleshooting skills.
- Excellent organizational, communication, and interpersonal skills.
Special Knowledge, Skills, and Abilities
Experience or familiarity with the following techniques and areas is highly desirable:
- Genomic and epigenomic assays.
- Stem cell and/or neuronal cell manipulation, including viral transduction and genome editing.
- RNA biochemistry and RNA-mediated gene regulation.
Requirements
- Ph.D. in molecular neurobiology or a closely related field
- Extensive experience in neuronal cell culture, including primary neurons and/or stem cell-derived neuronal models
- Strong experimental design and troubleshooting skills
- Excellent organizational, communication, and interpersonal skills
- Experience or familiarity with genomic and epigenomic assays
- Experience or familiarity with stem cell and/or neuronal cell manipulation, including viral transduction and genome editing
- Experience or familiarity with RNA biochemistry and RNA-mediated gene regulation
Benefits
- Comprehensive benefits package
Company overview
The Lieber Institute for Brain Development (LIBD) is a leading nonprofit research center dedicated to advancing the understanding and treatment of neuropsychiatric and neurodegenerative disorders. Founded in 2010 in Baltimore, Maryland, the institute operates as an independent 501(c)(3) organization affiliated with Johns Hopkins University School of Medicine. LIBD's mission focuses on translating genetic and molecular insights into next-generation treatments for brain disorders such as schizophrenia, autism, PTSD, mood disorders, and addiction. The institute maintains the world's largest collection of post-mortem brains for research purposes, with over 3,000 specimens that enable groundbreaking studies on the biological basis of mental illnesses. LIBD employs a multidisciplinary approach combining functional genomics, clinical pharmacology, data science, computational biology, and drug discovery to develop novel therapeutic interventions. The institute has established significant partnerships with academic institutions, pharmaceutical companies, and government agencies worldwide, and has launched important initiatives like the African Ancestry Neuroscience Research Initiative to address health disparities in neuroscience research.