Postdoctoral Fellow – Single-Cell Genomics & CRISPR Technology Development
Roche
Summary
The Darmanis and Regev labs are seeking a creative, rigorous, and motivated Postdoctoral Fellow to focus on technology development at the forefront of functional genomics, developing single-cell, CRISPR-based genetic perturbation screens and multi-omic technologies. You will engage with scientific collaborators across the community to solve fundamental biological questions and publish high-impact science.
Job description
The Opportunity
- Spearhead the design, development, and optimization of novel technologies for single-cell multi-omics, with a primary focus on high-throughput CRISPR genetic perturbation screens.
- Interpret and analyze complex single-cell genomics data using a variety of analytical methods and AI-based approaches.
- Collaborate with academic and scientific partners to advance novel technological platforms.
- Publish primary research in high-impact, peer-reviewed scientific journals and present scientific findings at internal seminars and international conferences.
Who You Are
- Education: PhD (or near completion) in Molecular Biology, Genetics, Biochemistry, Biomedical Engineering, Bioengineering, or a related scientific discipline.
- Core Technical Expertise: Strong background in molecular biology, genomics, cell biology, or bioengineering, with a demonstrated ability or enthusiasm to learn and apply single-cell multi-omic assays or CRISPR-based technologies.
- Sequencing Experience: Proficient in standard molecular biology techniques and NGS library preparation downstream of single-cell assays, with exposure to short- and long-read sequencing platforms.
- Data Analysis: Working knowledge of or proficiency in computational genomics analysis using R and/or Python.
- Publication Record: Demonstrated track record of scientific productivity, evidenced by first-author publications, preprints, or patent applications.
- Soft Skills: Excellent oral and written communication skills, strong problem-solving abilities, and an eagerness to thrive in a collaborative research environment.
Requirements
- PhD (or near completion) in Molecular Biology, Genetics, Biochemistry, Biomedical Engineering, Bioengineering, or a related scientific discipline
- Strong background in molecular biology, genomics, cell biology, or bioengineering
- Demonstrated ability or enthusiasm to learn and apply single-cell multi-omic assays or CRISPR-based technologies
- Proficient in standard molecular biology techniques and NGS library preparation downstream of single-cell assays
- Exposure to short- and long-read sequencing platforms
- Working knowledge of or proficiency in computational genomics analysis using R and/or Python
- Demonstrated track record of scientific productivity, evidenced by first-author publications, preprints, or patent applications
- Excellent oral and written communication skills
- Strong problem-solving abilities
- Eagerness to thrive in a collaborative research environment
Benefits
- Relocation benefits
- Competitive salary
- Fully funded research expenses
- Professional development workshops
- Networking opportunities
Company overview
Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.