Postdoctoral Research Associate - Surgery
St. Jude Children's Research Hospital
Summary
The Yang Lab in Department of Surgery at St. Jude Children's Research Hospital is seeking a highly motivated Postdoctoral Fellow to join our translational research team. The research focuses on understanding the novel functions of fusion transcriptional factors in rhabdomyosarcoma. This work is highly mechanistic and translational, leveraging cutting-edge genetic, epigenetic, cellular and pharmacologic tools to inform better therapies using human and genetic models.
Job description
Key Responsibilities
- Design and conduct experiments investigating the mechanism of chimeric transcriptional factors in regulating gene transcription.
- Evaluate preclinical efficacy of immunomodulators and the underlying mechanism.
- Collaborate within a multidisciplinary team including cancer biologists and clinicians.
- Present findings at national and international meetings and contribute to manuscript preparation and grant proposals.
Qualifications
- A Ph.D. (or nearing completion) in molecular biology, cancer biology, biochemistry, developmental biology, immunology, or related fields.
- Experience with mouse models, genome editing is a plus.
- Excellent communication skills, critical thinking, and a collaborative mindset.
- A strong publication record demonstrating scientific rigor and productivity.
Requirements
- A Ph.D. (or nearing completion) in molecular biology, cancer biology, biochemistry, developmental biology, immunology, or related fields.
- Experience with mouse models, genome editing is a plus.
- Excellent communication skills, critical thinking, and a collaborative mindset.
- A strong publication record demonstrating scientific rigor and productivity.
Company overview
St. Jude Children's Research Hospital is a world-renowned pediatric research and treatment institution headquartered in Memphis, Tennessee, dedicated to advancing cures for childhood cancer and other catastrophic diseases. Founded in 1962 by entertainer Danny Thomas, it stands as the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted exclusively to children. The hospital operates on a unique funding model where families never receive bills for treatment, travel, housing, or food, with costs exceeding $2 billion annually primarily supported by donations through its fundraising organization ALSAC. St. Jude treats approximately 8,600 patients each year from all 50 states and around the world, with a focus on acute lymphoblastic leukemia, brain tumors, sickle cell disease, and infectious diseases. The institution employs over 7,000 staff members and maintains eight affiliate clinics across the United States. Through its St. Jude Global initiative, the hospital shares research and treatment protocols internationally, partnering with more than 350 institutions in over 90 countries. St. Jude has been instrumental in increasing childhood cancer survival rates from 20% in 1962 to over 80% today, while maintaining a robust research program that includes gene therapy, bone marrow transplantation, and precision medicine approaches.