Principal Machine Learning Engineer
Amgen
Summary
Amgen's most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI solutions. Sitting at the intersection of engineering excellence and data-science enablement, you will develop, deploy and monitor models—classical ML, deep learning and LLMs—securely and cost-effectively. Acting as a 'player-coach,' you will establish AI solution strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI solutions.
Job description
Roles & Responsibilities
- Own enterprise AI/ML architecture, standards, APIs, and guardrails across cloud/on-prem.
- Build production ML/GenAI solutions and lightweight apps delivering sub-second insights.
- Build end-to-end ML pipelines —data ingestion, feature engineering, training, hyper-parameter optimisation, evaluation, registration and automated promotion—using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks.
- Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency.
- Establish observability, SLOs, and safe deploys (blue-green/canary, shadow, rollbacks) with incident runbooks.
- Lead rigorous evaluation (offline/online, A/B), drift detection, and automated retraining.
- Architect LLM/RAG with prompt management, safety guardrails, and optimized inference.
- Enforce data quality, lineage, and model/data cards; apply privacy-preserving techniques where needed.
- Contribute reusable ML/GenAI components —feature stores, model registries, experiment-tracking libraries—and evangelize best practices that raise engineering velocity across squads.
- Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness.
- Prototype and benchmark new algorithms, offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs.
- Translate domain needs (R&D, Manufacturing, Commercial) into roadmaps; mentor teams and communicate trade-offs.
Basic Qualifications
- Doctorate degree and 2 years of Machine Learning Engineer experience OR Master's degree and 6 years of Machine Learning Engineer experience OR Bachelor's degree and 8 years of Machine Learning Engineer experience OR Associate's degree and 10 years of Machine Learning Engineer experience OR High school diploma / GED and 12 years of Machine Learning Engineer experience
- Minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources.
- 3-5 years in AI/ML and enterprise software.
- Strong command of machine-learning algorithms — regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques—with the judgment to choose, tune and operationalize the right method for a given business problem.
- Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale.
- Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, LangGraph, Semantic Kernel).
- Proficiency in Python and Java; containerization (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines).
- Strong business-case skills—able to model TCO vs. NPV and present trade-offs to executives.
- Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives.
Preferred Qualifications
- Experience in Biotechnology or pharma industry is a big plus
- Published thought-leadership or conference talks on enterprise GenAI adoption.
- Master's degree in Computer Science and or Data Science
- Familiarity with Agile methodologies and Scaled Agile Framework (SAFe) for project delivery.
- Master's degree with 10-12 + years of experience in Computer Science, IT or related field OR Bachelor's degree with 12-14 + years of experience in Computer Science, IT or related field
- Certifications on GenAI/ML platforms (AWS AI, Azure AI Engineer, Google Cloud ML, etc.) are a plus.
Soft Skills
- Excellent analytical and troubleshooting skills.
- Strong verbal and written communication skills
- Ability to work effectively with global, virtual teams
- High degree of initiative and self-motivation.
- Ability to manage multiple priorities successfully.
- Team-oriented, with a focus on achieving team goals.
- Ability to learn quickly, be organized and detail oriented.
- Strong presentation and public speaking skills.
Requirements
- Doctorate degree and 2 years of Machine Learning Engineer experience OR Master's degree and 6 years of Machine Learning Engineer experience OR Bachelor's degree and 8 years of Machine Learning Engineer experience OR Associate's degree and 10 years of Machine Learning Engineer experience OR High school diploma / GED and 12 years of Machine Learning Engineer experience
- Minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources.
- 3-5 years in AI/ML and enterprise software.
- Strong command of machine-learning algorithms — regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques
- Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale.
- Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, LangGraph, Semantic Kernel).
- Proficiency in Python and Java; containerization (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines).
- Strong business-case skills—able to model TCO vs. NPV and present trade-offs to executives.
- Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives.
Benefits
- Retirement and Savings Plan
- Health insurance
- Dental insurance
- Vision coverage
- Life insurance
- Disability insurance
- Flexible spending accounts
- Discretionary annual bonus
- Stock-based long-term incentives
- Paid time-off
- Flexible work models
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.