Principal Research Scientist II, Process Chemistry
AbbVie
Summary
AbbVie Process Chemistry is responsible for the chemical development of AbbVie's clinical candidates. We are looking for a highly motivated Principal Research Scientist II who can make scientific contributions and develop strategies, timelines and key activities across drug substance modalities, including small molecules. The candidate must be able to mentor and develop staff with experimental approaches to solve difficult scientific and technical challenges. The candidate will be an integral part of project teams and will be responsible for developing the synthetic process and executing activities required for drug substance process development. Working with cross-functional colleagues, the candidate will develop productive collaborations and communications with scientific teams.
Job description
Responsibilities
- Participate and/or lead project teams associated with drug substance process development and characterization.
- Develop and characterize drug substance processes in the laboratory and translate them to scalable processes.
- Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
- Author and review key regulatory documents, laboratory data, technical memos and reports.
- Multi-disciplinary interactions with organic chemists, analytical chemists, engineers, drug product development, and program management.
- Identify and nurture ideas for continuous improvement activities and initiatives within the department.
- Set project strategies, define project responsibilities and timelines, develop control strategies, provide leadership in a matrixed team setting and develop robust processes for cGMP manufacturing.
Qualifications
- BS (16+ years); MS (14+ years) or PhD (8+ years) in Chemistry or allied field, with 8+ years of previous work experience in a pharmaceutical laboratory setting.
- Proven scientific leadership; strong interpersonal and communication skills for facilitating collaborations and a demonstrated ability to lead cross-functional process development teams.
- Experience with GMP drug substance manufacturing and process development.
- Experience in managing and developing scientific leaders.
- Strong understanding of modern organic chemistry, mechanistic theory, process development, control strategy development, and regulatory starting material strategies.
Key AbbVie Competencies
- Interacts well with diverse groups within function and maintains strong working relationships with internal and external collaborators to enable higher performance.
- Learns fast, grasps the essence and can change course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Requirements
- BS (16+ years); MS (14+ years) or PhD (8+ years) in Chemistry or allied field
- 8+ years of previous work experience in a pharmaceutical laboratory setting
- Proven scientific leadership
- Strong interpersonal and communication skills
- Demonstrated ability to lead cross-functional process development teams
- Experience with GMP drug substance manufacturing and process development
- Experience in managing and developing scientific leaders
- Strong understanding of modern organic chemistry
- Strong understanding of mechanistic theory
- Strong understanding of process development
- Strong understanding of control strategy development
- Strong understanding of regulatory starting material strategies
Benefits
- Paid time off
- Medical, Dental & Vision
- 401(k)
- Long-term incentive programs
Company overview
AbbVie is a global biopharmaceutical company that discovers, develops, and markets advanced therapies for some of the world's most complex and serious diseases. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie has established itself as a leader in immunology, oncology, neuroscience, eye care, and virology. The company's flagship product, Humira (adalimumab), was one of the world's top-selling drugs for treating autoimmune conditions like rheumatoid arthritis and Crohn's disease. AbbVie maintains a robust pipeline of innovative medicines and has expanded its portfolio through strategic acquisitions, including Allergan in 2020. With research facilities across the United States and globally, AbbVie focuses on advancing science to improve patient outcomes while maintaining strong commercial operations worldwide. The company operates with a patient-centric approach and invests significantly in research and development to address unmet medical needs across multiple therapeutic areas.