Principal Scientist – AI-Reasoning for Drug Discovery
Johnson & Johnson Innovative Medicine
Summary
The DDSAI-OCMO team is seeking a visionary Principal Scientist to architect an AI-Reasoning platform to support Translational Safety decision making in drug discovery and development. You'll pioneer the development of innovative reasoning platform that scientists can access through Large Language Models (LLMs) and agentic systems, harnessing Multimodal Scientific data across Discovery, Preclinical, Clinical, and RWE domains, harnessing large scale datasets spanning scientific literature, omics, biomolecular knowledge, and manufacturing processes to fundamentally transform how we bring therapeutics to patients.
Job description
Key Responsibilities
- Pioneer breakthrough multimodal AI systems that synthesize scientific data into actionable scientific insights which accelerate drug discovery
- Architect next-generation agent memory systems that establish how AI retains knowledge and makes context-aware decisions, creating persistent intelligence that evolves across the entire discovery-to-development pipeline
- Define the future of AI reliability in R&D by orchestrating groundbreaking research in uncertainty quantification and establishing new standards for trustworthy AI-driven scientific reasoning
- Shape the scientific vision as an inspiring leader, translating emerging AI/ML frontiers into transformative applications while mentoring teams to push the boundaries of what's possible in computational drug discovery
- Drive scientific validation and impact by rigorously benchmarking AI agents against top human experts and state-of-the-art methods, with the opportunity to publish paradigm-shifting findings in premier venues
Required Qualifications
- Ph.D. in AI/ML or related fields (computer science, machine learning, data science, applied mathematics, statistics) with 2+ years of proven experience
- Deep expertise in sophisticated mathematical frameworks including Bayesian inference, uncertainty quantification, information theory, causal inference, graph neural networks, and related methodologies that advance the field of agentic reasoning
- Proficiency with agentic frameworks (LangGraph, DSPy, mem0) and deep learning platforms (PyTorch, TensorFlow), and extend these tools for novel scientific applications
- Exceptional Python programming skills, capable of architecting scalable solutions that bridge innovation and production deployment
- The ability to lead small teams of researchers to achieve success in their work
Preferred Qualifications
- Understanding of drug discovery pipeline and familiarity with biological data types
- Strong understanding of statistics and applicable methods to validate model performance
- Familiarity with cloud hosting solutions (ex. AWS and/or Azure)
Requirements
- Ph.D. in AI/ML or related fields (computer science, machine learning, data science, applied mathematics, statistics) with 2+ years of proven experience
- Deep expertise in Bayesian inference, uncertainty quantification, information theory, causal inference, graph neural networks
- Proficiency with agentic frameworks (LangGraph, DSPy, mem0) and deep learning platforms (PyTorch, TensorFlow)
- Exceptional Python programming skills
- Ability to lead small teams of researchers
- Understanding of drug discovery pipeline and familiarity with biological data types
- Strong understanding of statistics and applicable methods to validate model performance
- Familiarity with cloud hosting solutions (AWS and/or Azure)
Benefits
- Pension Plan
- 401(k) Savings Plan
- Long-Term Incentive Program
- Vacation
- Sick Time
- Holiday Pay
- Floating Holidays
- Parental Leave
- Bereavement Leave
- Caregiver Leave
- Volunteer Leave
- Military Spouse Time-Off
Company overview
Johnson & Johnson Innovative Medicine is the pharmaceutical division of Johnson & Johnson, leading the way in medical innovation with a relentless focus on bringing transformational treatments to patients worldwide. The company applies rigorous science and compassion to address the most complex diseases of our time, developing groundbreaking medicines across key therapeutic areas including oncology, immunology, neuroscience, and cardiopulmonary medicine. With deep expertise and global reach, Johnson & Johnson Innovative Medicine reimagines how devastating diseases are treated and cured, delivering hope and better care for millions of patients and their families. The organization pioneers the path from laboratory research to clinical application, championing patients every step of the way while maintaining an unwavering commitment to scientific excellence and patient-centered innovation.