Principal Scientist, Discovery-Oncology

Candidates should have expertise in cancer biology or immunology, and the mechanisms required to trigger robust anti-tumor response. Additionally, candidates must demonstrate direct experience in small/large molecule design and/or combination strategies to overcome solid tumor microenvironment. Furthermore, knowledge of current assays required to characterize optimal T-cell functional performance is a requirement. Successful candidates are expected to drive future innovation around TCE design by identifying enabling technologies through either internal or external efforts. Candidates must demonstrate prior program leadership experience in industry and must have a track record of excellence in managing projects and collaborating effectively with colleagues in other functional areas.

The Principal Scientists will:

• Work with and/or lead a team of scientists in nominating candidates for discovery portfolio programs
• Plan, develop and execute state-of-the-art assays that enable the identification of optimal TCE candidates to maximize therapeutic potential and durability in solid tumors
• Partner with leaders in other therapeutic areas to select optimal binders, molecular configuration and delivery strategies
• While delivering on prioritized goals, foster a culture of scientific excellence and innovation
• Eliminate barriers to collaboration across workstreams and functions by encouraging a culture of open communication and transparency
• Contribute to intellectual property, public presentations, and manuscript writing.
• Identify partnerships in academia to compliment key research initiatives
• Mentor junior scientists on the team, and promote personal and professional development

Qualifications

• Demonstrate matrixed leadership behavior and capabilities including design, guide, and perform highly complex experiments, accurately interpret data, and effectively communicate impact to stakeholders through formal and informal disclosures
• Ph.D. in Cancer Biology and/or Immunology with at least 6+ years of industry experience leading Discovery programs and teams, or performing progressively advanced duties at the Principal Scientist level, or the equivalent training/experience
• Hands-on experience with TCE or small molecule therapeutics, and a track record of successfully advancing therapeutic candidates through lead selection and IND-enabling activities
• Possess drug development knowledge
• Demonstrate track record of innovating in the drug discovery space. Constantly seek new technologies, processes, and techniques. Able to identify, implement, and master new models and improvements
• Able to integrate diverse subject areas to achieve research objectives
• Experienced supporting research collaborations with academic institutions, industry partners and research institutions
• Possess highly effective verbal and written communication skills