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Principal Scientist I

AbbVie

Irvine, CAOnsitePosted 2 days agoUSD 124500 - USD 236500 - yearly
Full TimeSenior LevelResearch & ScientistPharmaceutical
Original posting ↗

Summary

Allergan Aesthetics Biological Research is seeking a highly motivated and innovative scientist to direct and contribute to multidisciplinary research in a highly collaborative environment. The successful candidate will lead a team of in vivo pharmacology scientists who design and perform pharmacology studies, using existing and novel assays to evaluate the effects of therapeutic proteins on muscle paralysis.

Job description

The ideal candidate will be a recognized leader and technical expert in their field who will lead their team to execute effectively on critical research to address project and franchise needs. The ideal candidate will have a strong, established background in pharmacology, with a specialization in in vivo pharmacology, and a proven track record of successfully leading diverse, matrixed project teams to advance novel therapeutics into development.

Key Responsibilities

  • Demonstrate a high level of proficiency and expertise in his/her discipline.
  • Drive functional excellence by leading team members in designing and performing in vivo assays, analyzing pharmacological results to answer scientific questions, and ensuring timely delivery of data and presentations.
  • Set functional goals and experimental timelines and execute a strategy that aligns with the goals and key scientific objectives of the Biological Research department and the Neuroscience and Aesthetic Franchises.
  • Manage team priorities and activities and develop the skills and careers of direct reports through effective mentoring, training, and supervision.
  • Ensure the team understands the broad objectives of the projects they are supporting and their role in achieving them.
  • Demonstrate creative 'out of the box' thinking to solve difficult problems, champion new technologies, and independently modify experimental plans when required to achieve project goals.
  • Collaborate and develop strong working relationships with cross-functional team members to advance discovery programs into clinical studies, including potentially supporting later development goals.
  • Make significant contributions to project teams through lab-based, or other work environment activities.
  • Develop forward-looking strategies to identify and implement novel assays, measurements, and technologies that increase throughput, quality, and reproducibility of pharmacological results.
  • Advance scientific expertise within the function and stay current on emerging literature and science, integrate new trends from internal and external sources into short-term functional objectives.
  • Provide expert advice and share knowledge with direct reports, peers, and senior management.
  • Oversee data management and QC, author technical documents and publications, including protocols, study reports, relevant sections of regulatory filings, and other similar documents.
  • Effectively organize and present program updates and research strategies to cross-functional partners and leaders across the discovery and development organizations.
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug, and animal welfare where applicable.

Qualifications

  • Extensive experience with pharmacological assays, focusing on in vivo pharmacology in an industrial research environment, with at least 6+ years of experience managing teams and/or cross-functional projects.
  • Direct experience with peripheral animal models and measurements is an advantage.
  • Strong knowledge and experience in neuroscience, both central and peripheral, animal anatomy and histological assays and methods.
  • Highly organized and self-directed, capable of leading multiple complex research programs in parallel.
  • Detail-oriented, with a demonstrated commitment to accuracy and thoroughness in documenting experimental plans, timelines, study results, and technical reports.
  • Demonstrated experience authoring and contributing to a variety of documentation and presentations, including technical reports and regulatory documents.
  • Proven leadership and management abilities, including mentoring, guiding, supervising, and developing scientific personnel of varied backgrounds and training levels, while supporting multiple complex research programs in parallel.
  • Solid understanding of statistical analysis of scientific data using software tools (e.g., Prism, SigmaPlot, SPSS).
  • Effective problem-solving skills, with the ability to lead teams to resolve issues and make sound strategic decisions.
  • Effective written and oral communication, and strong interpersonal skills for working with diverse internal groups and external partners.
  • Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view.

Education & Experience

PhD in Biology, Pharmacology, Neuroscience, Biochemistry, or equivalent field with 6+ years of related work experience in biotech or pharma; Master's Degree Science or PharmD with 12+ years of related work.

Requirements

  • Extensive experience with pharmacological assays, focusing on in vivo pharmacology in an industrial research environment
  • At least 6+ years of experience managing teams and/or cross-functional projects
  • Strong knowledge and experience in neuroscience, both central and peripheral, animal anatomy and histological assays and methods
  • Highly organized and self-directed, capable of leading multiple complex research programs in parallel
  • Detail-oriented with commitment to accuracy in documenting experimental plans, timelines, study results, and technical reports
  • Demonstrated experience authoring technical reports and regulatory documents
  • Proven leadership and management abilities including mentoring, supervising, and developing scientific personnel
  • Solid understanding of statistical analysis using software tools (e.g., Prism, SigmaPlot, SPSS)
  • Effective problem-solving skills and ability to make sound strategic decisions
  • Effective written and oral communication and strong interpersonal skills
  • Ability to create an inclusive environment valuing diverse ideas and backgrounds
  • PhD in Biology, Pharmacology, Neuroscience, Biochemistry, or equivalent field with 6+ years of related work experience in biotech or pharma; or Master's Degree Science or PharmD with 12+ years of related work

Benefits

  • Paid time off
  • Medical, Dental & Vision
  • 401(k)
  • Long-term incentive programs

Company overview

AbbVie is a global biopharmaceutical company that discovers, develops, and markets advanced therapies for some of the world's most complex and serious diseases. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie has established itself as a leader in immunology, oncology, neuroscience, eye care, and virology. The company's flagship product, Humira (adalimumab), was one of the world's top-selling drugs for treating autoimmune conditions like rheumatoid arthritis and Crohn's disease. AbbVie maintains a robust pipeline of innovative medicines and has expanded its portfolio through strategic acquisitions, including Allergan in 2020. With research facilities across the United States and globally, AbbVie focuses on advancing science to improve patient outcomes while maintaining strong commercial operations worldwide. The company operates with a patient-centric approach and invests significantly in research and development to address unmet medical needs across multiple therapeutic areas.

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