Principal Scientist, Mass Spectrometry
BeiGene
Summary
As a Principal Scientist at BeOne Institute, you will play a key role in conceptualizing, enabling, and driving cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches that expand the frontiers of drug discovery.
Job description
Essential Functions of the Job
- Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities.
- Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.
- Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.
- Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.
- Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.
- Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.
- Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.
- Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.
Supervisory Responsibilities
- May be a contact for external CRO partners when needed
- May provide matrix or line-function leadership for project teams when needed
Computer Skills
- Proficiency with mass spectrometry data acquisition, processing, and analysis software.
- Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets.
- Experience with software and tools for MS-based screening and assay development.
Required Qualifications
- Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.
- Deep expertise in mass spectrometry, with demonstrated hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.
- Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows.
- Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
- Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
- Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays.
- Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets
- Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities
- Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches
- Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
- Be able to work on-site in San Carlos, CA
Preferred Qualifications
- Experience with Orbitrap systems (Astral a plus) and Agilent Q-TOFs strongly preferred.
- Knowledge of cancer pathways.
- Experience with ASMS and APMS workflows (in a drug discovery setting a plus).
Requirements
- Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline
- 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience
- Deep expertise in mass spectrometry, with demonstrated hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation
- Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows
- Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
- Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation
- Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays
- Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets
- Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities
- Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches
- Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
- Be able to work on-site in San Carlos, CA
- Proficiency with mass spectrometry data acquisition, processing, and analysis software
- Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets
- Experience with software and tools for MS-based screening and assay development
Benefits
- Medical, Dental & Vision
- 401(k)
- FSA/HSA
- Life Insurance
- Paid Time Off
- Wellness
- Annual bonus plan
- Discretionary equity awards
- Employee Stock Purchase Plan
Company overview
BeiGene, Ltd., now rebranding as BeOne Medicines, is a global commercial-stage biotechnology company specializing in the discovery, development, manufacturing, and commercialization of innovative oncology medicines. Founded in 2010 by John V. Oyler and Xiaodong Wang, the company has grown into a multinational organization with headquarters in Cambridge, Massachusetts, Beijing, China, and Basel, Switzerland. BeiGene focuses on developing targeted and immune-oncology therapies for cancer treatment, with a diverse pipeline that includes internally discovered products like BRUKINSA (zanubrutinib), a Bruton's tyrosine kinase inhibitor, and Tevimbra (tislelizumab), a PD-1 inhibitor. The company operates across six continents with over 45 countries participating in clinical trials and has enrolled more than 30,000 patients in its research programs. With approximately 12,000 employees worldwide, BeiGene has established itself as a significant player in global oncology, particularly with strong market presence in China and expanding operations in the United States and Europe. The company's mission centers on expanding access to high-quality cancer therapies worldwide through persistent innovation and challenging traditional approaches to drug development.