Principal Scientist - Medicinal Chemistry
Amgen
Summary
In this vital role you will be part of an innovative Medicinal Chemistry group, with responsibilities including the design, synthesis, and purification of novel compounds for potential clinical drug development. This includes the opportunity to work within Amgen's Induced Proximity Platform (IPP), focused on novel approaches to modulate intractable targets using the emerging PROTAC modality. This is an onsite laboratory position at our South San Francisco site.
Job description
What you will do
In this vital role you will be part of an innovative Medicinal Chemistry group, with responsibilities including the design, synthesis, and purification of novel compounds for potential clinical drug development. This includes the opportunity to work within Amgen's Induced Proximity Platform (IPP), focused on novel approaches to modulate intractable targets using the emerging PROTAC modality. This is an onsite laboratory position at our South San Francisco site.
Responsibilities
- Devise and implement state of the art scientific research through conducting laboratory experiments, planning detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results and necessary resources
- Review, analyze, and interpret scientific data and results; provide regular updates, documentation, and/or communication on project results; collaborate with other scientists and keep current with field of expertise, including literature and technology development
- Advise supervisors and colleagues in areas of expertise; participate in national and international meetings; provide scientific results that support the generation of publications or patents; mentor research associates and laboratory assistants
Basic Qualifications
- Doctorate degree and 2 years of scientific experience
- Master's degree and 5 years of scientific experience
- Bachelor's degree and 7 years of scientific experience
Preferred Qualifications
- Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry
- Experience leading medicinal chemistry teams and delivering candidates for clinical development
- Extensive track record of consistent and successful drug discovery accomplishments (e.g. patent inventor-ship, conference presentations, and peer-reviewed publications)
- Deep understanding of drug discovery and relevant drug discovery disciplines (e.g. chemistry, biology, safety, PKDM, etc.)
- Expert in modern medicinal and synthetic chemistry approaches
- Excellent collaboration and communication skills (both written and oral)
Requirements
- Doctorate degree and 2 years of scientific experience, or Master's degree and 5 years of scientific experience, or Bachelor's degree and 7 years of scientific experience
- Doctorate degree in chemistry specializing in organic chemistry and 6+ years of experience in synthetic organic and medicinal chemistry (preferred)
- Experience leading medicinal chemistry teams and delivering candidates for clinical development (preferred)
- Extensive track record of successful drug discovery accomplishments (preferred)
- Deep understanding of drug discovery and relevant disciplines (preferred)
- Expert in modern medicinal and synthetic chemistry approaches (preferred)
- Excellent collaboration and communication skills (preferred)
Benefits
- Retirement and Savings Plan
- Medical, Dental & Vision
- Life and Disability Insurance
- Flexible Spending Accounts
- Annual Bonus Program
- Stock-Based Long-Term Incentives
- Award-Winning Time-Off Plans
- Career Development Opportunities
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.