Principal Scientist, SOP & Workflow Automation Champion, AI for Drug Discovery (AIDD)

The Opportunity

At Roche's AI for Drug Discovery (AIDD) group within the Computational Sciences Center of Excellence, we are architecting a vision for end-to-end computational drug discovery. We are building a unified, modular system where machine learning methods integrate seamlessly into executable, agentic workflows that empower scientists across our organization to discover better medicines faster.

We're looking for an exceptional Principal Scientist who can architect how our computational models become standard operating procedures (SOPs) and automated workflows that portfolio teams actually use, depend on, and trust.

In this role, you will:

• Design computational workflow architecture that operationalizes modular ML components into scalable, reproducible, and agentic-ready systems
• Lead the development and standardization of SOPs for model integration, data pipelines, and workflow execution across gRED and pRED
• Partner strategically with Roche's platform engineering teams to implement workflows at scale
• Architect data integration with Roche's centralized data infrastructure (DDC), ensuring seamless model-data-workflow loops
• Collaborate with the modeling team to translate research-stage models into production-ready components with clear interfaces, performance benchmarks, and failure modes
• Navigate complex stakeholder environments, including portfolio teams, platform organizations, and technology development groups, to align on standards and drive adoption
• Lead and mentor engineers and scientists on workflow design, automation best practices, and computational architecture

Who you are

Technical Foundation

• PhD in Computer Science, Computational Biology, Bioinformatics, or related field, or equivalent advanced experience (8+ years building computational systems)
• Deep expertise in workflow orchestration, data pipeline design, and software architecture (not just machine learning)
• Proven experience designing systems that integrate heterogeneous data sources, models, and processes at scale
• Strong proficiency in Python and modern ML frameworks (PyTorch, TensorFlow, JAX); familiarity with workflow tools (Nextflow, Snakemake, Airflow, or similar)
• Understanding of software engineering practices: version control, testing, documentation, CI/CD pipelines

Experience in Life Sciences / Drug Discovery

• Demonstrated experience working at the intersection of computational methods and experimental biology
• Understanding of drug discovery workflows: what scientists actually need, where handoffs break down, how to design for usability
• Track record of translating research code into production systems that real teams use
• Experience working across technical and non-technical stakeholders (biology, chemistry, engineering)

Leadership & Collaboration

• Proven ability to lead complex, cross-functional initiatives involving multiple teams and organizations
• Track record of driving adoption of new standards, tools, or processes in larger organizations
• Strong communication skills: can explain complex technical concepts to diverse audiences and build consensus
• First-author publications or equivalent evidence of research contributions

Strategic Thinking

• You see the gap between "research works in a paper" and "research works at scale in an organization"
• You understand how to design systems for reliability, debuggability, and adoption
• You can balance scientific rigor with pragmatic engineering constraints