Process Engineer, Kilo and High Potency Lab, Lilly Medicine Foundry
Eli Lilly and Company
Summary
We are seeking a Process Engineer to support the pilot plant facility in Lebanon, with a focus on small molecule Kilo Lab and High Potency Lab operations. This position involves solving technical challenges with kilo-scale reactor and scale-up equipment design, developing and sustaining process knowledge for both standard and high-potency (HPAPI) chemistries, optimizing processes across synthesis, crystallization, distillation, and isolation unit operations, and managing equipment capabilities and containment strategies for the Kilo Lab and High Potency Lab suites.
Job description
Responsibilities
- Evaluate scale-up feasibility and rig fit for new chemistries by analyzing technical data packages and running kinetic, mass-transfer, and heat-transfer modeling and experiments to ensure clean transfer from gram- to kilogram-scale reactors.
- Design, test and install new equipment to meet the evolving portfolio and reaction needs.
- Design, operate, and troubleshoot kilo-scale reactor systems — glass-lined and Hastelloy reactors, agitated filter-dryers — partnering with Kilo Lab and High Potency Lab chemists and shaping plant design for piping, mixing, heat transfer, and automation.
- Engineer containment and safe-handling strategies for HPAPI operations, spanning isolator and glove-box systems, occupational exposure banding (OEB), and dry-end solids processing.
- Optimize crystallization, distillation, extraction, and isolation unit operations, resolving polymorphism and particle-size challenges while closing mass balances and tracking impurity fate and purge across multi-step syntheses.
- Safeguard quality, safety, and cGMP compliance across equipment and procedures, and author or review technical reports, regulatory submissions, and lab notebooks to a high standard.
- Drive cross-functional execution by conducting impact and risk assessments, coordinating with HSE, QA, Tech Services, Development, Operations, Automation, and Manufacturing, and developing project plans and timetables with a proactive quality mindset.
- Develop or review plans and timetables for project work.
Requirements
- BS or MS in chemical engineering or related discipline
- Minimum of 1-4 years of experience with a pharmaceutical, biotech, or CMO environment supporting the process engineering of drug substance active pharmaceutical ingredient (API) manufacturing or development
- Qualified applicants must be authorized to work in the United States on a full-time basis
- Lilly will not provide support for or sponsor work authorization or visas for this role
Benefits
- 401(k)
- Pension
- Vacation benefits
- Medical, Dental & Vision
- Prescription drug benefits
- Flexible spending accounts
- Life insurance
- Death benefits
- Employee assistance program
- Fitness benefits
- Employee clubs and activities
Company overview
Eli Lilly and Company, commonly known as Lilly, is a leading American multinational pharmaceutical corporation headquartered in Indianapolis, Indiana. Founded in 1876 by Colonel Eli Lilly, the company has grown into one of the world's most valuable pharmaceutical enterprises, with operations in approximately 125 countries. Lilly specializes in developing and manufacturing innovative medicines across multiple therapeutic areas, including diabetes, oncology, neuroscience, immunology, and cardiometabolic diseases. The company is renowned for its groundbreaking work in insulin production, having been the first to mass-produce insulin and later developing the first commercially available insulin product in the U.S. Lilly's current portfolio includes blockbuster medications such as Mounjaro and Zepbound (tirzepatide) for diabetes and obesity, Trulicity (dulaglutide) for type 2 diabetes, Verzenio (abemaciclib) for breast cancer, and Taltz (ixekizumab) for autoimmune conditions. With approximately 47,000 employees worldwide, Lilly maintains a strong commitment to research and development, investing heavily in scientific innovation to address some of the world's most significant health challenges. The company operates with a mission to make life better for people around the world through the discovery and delivery of innovative medicines.