Process modeling (Protein/Antigen) Principal Data Scientist
Sanofi
Summary
As Principal Data Scientist within our Process Modeling – Vaccines R&D Data & Computational Science team, you'll lead the development of AI, machine learning, and hybrid modeling solutions that accelerate the future of recombinant protein vaccine manufacturing.
Job description
About the Job
As Principal Data Scientist within our Process Modeling – Vaccines R&D Data & Computational Science team, you'll lead the development of AI, machine learning, and hybrid modeling solutions that accelerate the future of recombinant protein vaccine manufacturing.
In this role, you'll work closely with process development, analytical, and manufacturing teams to improve process understanding and optimize performance across CHO cell culture, baculovirus expression systems, protein purification, and cell line development.
Main Responsibilities
- Lead the development and deployment of AI, machine learning, mechanistic, and hybrid modeling solutions to accelerate recombinant protein vaccine process development and manufacturing.
- Apply advanced analytics to identify critical process parameters, predict product quality, improve yield, and optimize process performance.
- Develop modeling solutions for upstream processes, including CHO cell culture, baculovirus and insect cell expression systems, and cell line development.
- Support optimization of downstream purification operations, including chromatography, filtration, and ultrafiltration/diafiltration, through data-driven and model-based approaches.
- Build and deploy digital twins, simulation tools, and decision-support frameworks to support process optimization, scale-up, technology transfer, and lifecycle management.
- Collaborate with process development, analytical sciences, manufacturing, and digital teams to integrate process knowledge and data into actionable insights.
- Provide scientific leadership and mentorship in AI, machine learning, data science, and process modeling across the organization.
About You
Basic Qualifications
Education: Ph.D. in Chemical Engineering, Bioengineering, Biotechnology, Computational Biology, Data Science, Applied Mathematics, or a related scientific discipline.
Experience: 2+ years of relevant experience in the pharmaceutical industry.
Preferred Qualifications
- Background applying data science, machine learning, and process modeling in biopharmaceutical, biologics, vaccine, or related development environments, including recombinant protein production and manufacturing.
- Expertise in AI, machine learning, multivariate data analysis, mechanistic and hybrid modeling, digital twins, process simulation, Bayesian optimization, and Design of Experiments, including model-based approaches.
- Experience supporting CHO cell culture, baculovirus expression systems, protein purification, and/or cell line development.
- Proficiency in scientific computing and modeling platforms such as Python, R, MATLAB, JMP, gPROMS, GoSilico, or equivalent tools.
- Strong scientific leadership, problem-solving, communication, and cross-functional collaboration skills.
- Fluent English required.
Requirements
- Ph.D. in Chemical Engineering, Bioengineering, Biotechnology, Computational Biology, Data Science, Applied Mathematics, or a related scientific discipline
- 2+ years of relevant experience in the pharmaceutical industry
- Fluent English required
Benefits
- Health insurance
- Prevention and wellness programs
- Gender-neutral parental leave
- Career growth opportunities
Company overview
Sanofi is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Founded in 1973, the company has grown through strategic mergers and acquisitions to become one of the world's leading pharmaceutical corporations. Sanofi operates as an R&D-driven, AI-powered biopharma company committed to improving people's lives through breakthrough science. The company's portfolio spans seven major therapeutic areas including cardiovascular diseases, diabetes, oncology, immunology, rare diseases, neurology, and vaccines. Through its subsidiary Sanofi Pasteur, it is the world's largest producer of vaccines. Sanofi employs over 84,000 people across more than 100 countries and maintains a significant presence in both developed and emerging markets. The company's innovative pipeline focuses on advancing precision medicines and biologics while maintaining a strong commitment to sustainability and ethical business practices. Sanofi's mission centers on chasing the miracles of science to deliver transformative healthcare solutions globally.