Protein Analytical Scientist – Mass Spectrometry (Large Molecules)
Thermo Fisher Scientific
Summary
We are looking for a motivated individual to join our Global Bioproduction Analytics Team. This position supports a cross-functional team working toward the design and commercialization of new cell culture media and media supplement products. The successful candidate will have extensive experience with high-resolution LC-MS workflows for large molecules, including monoclonal antibodies (mAbs), bispecific antibodies (bsAbs), antibody-drug conjugates (ADCs), and other therapeutic proteins. This role requires strong analytical problem-solving skills, the ability to interpret complex datasets, and close collaboration with cross-functional teams to deliver high-quality analytical solutions that accelerate cell culture media development.
Job description
What You Will Do
- Develop, optimize, and execute LC-MS methods for the characterization of therapeutic proteins using high-resolution mass spectrometry platforms.
- Analyze and interpret complex mass spectrometry datasets to identify and characterize post-translational modifications (PTMs), sequence variants, chain mispairing, and structural attributes of monoclonal antibodies, bispecific antibodies, ADCs, and other protein therapeutics.
- Characterize critical quality attributes (CQAs), including glycan heterogeneity, charge variants, aggregation, and molecular integrity using orthogonal analytical techniques.
- Perform intact mass analysis, middle-down characterization, peptide mapping, and other large molecule MS-based workflows.
- Prepare clear, accurate, and scientifically sound reports, technical presentations, and analytical documentation for internal and external stakeholders.
- Troubleshoot analytical methods, investigate unexpected results, and recommend scientifically justified solutions.
- Perform routine testing, maintenance, troubleshooting, and performance verification of mass spectrometers, liquid chromatography systems, and associated instrumentation to ensure reliable operation.
- Stay up-to-date with the latest technological and practical advancements in the field of analytical chemistry as they pertain to cellular processes.
How You Will Get Here
Minimum Qualifications: Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with 0–3 years of relevant experience; or M.S. with 3+ years; or B.S. with 6+ years of relevant industry experience.
Preferred Qualifications: Strong background in analytical chemistry, protein biochemistry, or biopharmaceutical characterization. Hands-on experience operating high-resolution mass spectrometry platforms (e.g., Orbitrap or equivalent). Demonstrated expertise in LC-MS method development and optimization for large molecule characterization. Experience with MAM and iMAM workflows is a plus. Experience with intact mass analysis, middle-down workflows, peptide mapping, and disulfide bond characterization is a plus. Proven experience characterizing monoclonal antibodies, bispecific antibodies, antibody fragments, antibody-drug conjugates, or related therapeutic proteins. Knowledge of protein post-translational modifications, glycosylation analysis, charge variant analysis, aggregation analysis, and higher-order structure characterization. Experience using data analysis software for mass spectrometry interpretation and reporting. Excellent troubleshooting, critical thinking, and problem-solving skills. Strong written and verbal communication skills with the ability to present complex analytical data to diverse audiences. Ability to manage multiple projects in a fast-paced, collaborative environment while maintaining high scientific and quality standards.
Requirements
- Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with 0–3 years of relevant experience; or M.S. with 3+ years; or B.S. with 6+ years of relevant industry experience.
- Strong background in analytical chemistry, protein biochemistry, or biopharmaceutical characterization.
- Hands-on experience operating high-resolution mass spectrometry platforms (e.g., Orbitrap or equivalent).
- Demonstrated expertise in LC-MS method development and optimization for large molecule characterization.
- Experience with MAM and iMAM workflows is a plus.
- Experience with intact mass analysis, middle-down workflows, peptide mapping, and disulfide bond characterization is a plus.
- Proven experience characterizing monoclonal antibodies, bispecific antibodies, antibody fragments, antibody-drug conjugates, or related therapeutic proteins.
- Knowledge of protein post-translational modifications, glycosylation analysis, charge variant analysis, aggregation analysis, and higher-order structure characterization.
- Experience using data analysis software for mass spectrometry interpretation and reporting.
- Excellent troubleshooting, critical thinking, and problem-solving skills.
- Strong written and verbal communication skills with the ability to present complex analytical data to diverse audiences.
- Ability to manage multiple projects in a fast-paced, collaborative environment while maintaining high scientific and quality standards.
Benefits
- Medical, Dental & Vision
- Health incentive programs
- Employee assistance program
- Family support programs
- Commuter benefits
- Tuition reimbursement
- Paid time off
- Paid holidays
- Paid parental leave
- Accident insurance
- Life insurance
- Short-term disability
- Long-term disability
- 401(k) retirement plan
- Employee stock purchase plan
Company overview
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. The company's mission is to enable customers to make the world healthier, cleaner, and safer. With over 100,000 employees globally, Thermo Fisher provides an unrivaled combination of innovative technologies, purchasing convenience, and pharmaceutical services through its industry-leading brands including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. The company serves customers across healthcare, life sciences, applied markets, and pharmaceutical sectors, offering solutions that accelerate research, solve complex analytical challenges, improve patient diagnostics, and increase laboratory productivity. Headquartered in Waltham, Massachusetts, Thermo Fisher operates globally, delivering critical scientific products, services, and workflow solutions that support researchers, organizations, and companies in addressing some of the world's most pressing issues.