Research Associate, Biology
Stoke Therapeutics
Summary
The Research Associate will support ongoing research efforts in designing and evaluating antisense therapies for diverse group of diseases. This position will report to a Scientist II in the Discovery Biology Group.
Job description
Position Purpose
The Research Associate will support ongoing research efforts in designing and evaluating antisense therapies for diverse group of diseases. This position will report to a Scientist II in the Discovery Biology Group.
Key Responsibilities
- Work in aseptic conditions and maintain cultures of various cell types.
- Screen and evaluate ASOs in relevant mouse tissues and cell-based assays.
- Perform cell and molecular biology techniques such as RNA, DNA and protein isolation, RT-PCR, RT-qPCR, ELISA and other project-specific assays, as necessary.
- Troubleshoot experiments, analyze and interpret data, participate in development of new assays with support from more senior scientists.
- Maintain accurate documentation of experiments in electronic lab notebook (ELN).
- Present research findings at group meetings.
- Other duties as assigned.
Required Skills & Experience
- BS with 2 years of post-graduate experience in molecular and cell biology research, preferably in industry or a Master's degree in molecular or cellular biology.
- Strong background in cell culture including experience is required. Experience with transfection methods and neuronal cell culture is a plus.
- Strong background in cell and molecular biology research; understanding of the basics of PCR is a must.
- Hands-on experience in RNA isolation techniques from cells and tissues, mammalian cell culture and cell-based assays is strongly desirable.
- Strong organizational and recordkeeping skills is a must.
- Ability to adapt to changing priorities and deadlines.
- Excellent planning and time management skills including the ability to support and prioritize multiple projects.
Requirements
- BS with 2 years of post-graduate experience in molecular and cell biology research, preferably in industry, or a Master's degree in molecular or cellular biology
- Strong background in cell culture
- Experience with transfection methods and neuronal cell culture is a plus
- Strong background in cell and molecular biology research
- Understanding of the basics of PCR
- Hands-on experience in RNA isolation techniques from cells and tissues, mammalian cell culture and cell-based assays is strongly desirable
- Strong organizational and recordkeeping skills
- Ability to adapt to changing priorities and deadlines
- Excellent planning and time management skills including the ability to support and prioritize multiple projects
Benefits
- Annual Bonus
- Equity Participation
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Long-Term Disability Insurance
- Short-Term Disability Insurance
- Paid Parental Leave
- 401(k) With Company Match
- Unlimited Vacation Time
- Tuition Assistance
- Employee Stock Purchase Program
Company overview
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to developing novel RNA-based medicines for severe genetic diseases. Founded in 2014 and headquartered in Bedford, Massachusetts, the company employs its proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach to create antisense oligonucleotides (ASOs) that selectively restore naturally-occurring protein levels. Stoke's innovative platform focuses on haploinsufficiency diseases where patients have approximately 50% of normal protein levels, primarily targeting conditions affecting the central nervous system and eyes. The company's lead investigational medicine, zorevunersen (STK-001), is currently in Phase 3 clinical trials for Dravet syndrome, a severe form of childhood epilepsy, and has demonstrated promising disease-modifying potential. Stoke also has preclinical programs including STK-002 for autosomal dominant optic atrophy. The company has established strategic collaborations with industry leaders like Biogen for Dravet syndrome development and Acadia Pharmaceuticals for neurodevelopmental disorders. With approximately 51-200 employees, Stoke Therapeutics represents a pioneering force in RNA medicine, aiming to address unmet medical needs in rare genetic diseases through its innovative protein restoration technology.