Research Associate I/II, Protein Sciences
Flagship Pioneering, Inc.
Summary
We are seeking a highly motivated Research Associate to support recombinant protein production at Fathem. This role will focus on the expression, purification, and characterization of challenging protein targets—including membrane proteins and other cryo-EM–ready samples—with an emphasis on high-throughput, high-quality data generation.
Job description
Role Summary
We are seeking a highly motivated Research Associate to support recombinant protein production at Fathem. This role will focus on the expression, purification, and characterization of challenging protein targets—including membrane proteins and other cryo-EM–ready samples—with an emphasis on high-throughput, high-quality data generation.
You will work at the intersection of protein biochemistry, structural biology, and AI-driven technology development, building robust purification workflows and characterization assays that directly feed data into next-generation computational models. This is a hands-on, fast-moving role for someone who enjoys solving hard biochemical problems and seeing their work rapidly translate into new insights and capabilities.
Basic Requirements
- Bachelor's degree in Biochemistry or a related field, with a minimum of 2 years relevant experience in an academic or industry laboratory or a MS degree in Biochemistry or a related field
- Hands-on experience in recombinant protein expression and purification, encompassing all steps of the end-to-end workflow: transformation/transfection, and the full range of chromatographic techniques (affinity, ion-exchange, and size-exclusion)
- Familiarity with protein construct design and analytical techniques used to assess recombinant protein quality, including size-exclusion chromatography, dynamic light scattering, and thermostability assays
- Proven ability to rigorously document their work in an ELN and maintain lab organization and inventories
Strong Candidates Will Have
- More than one year of experience with recombinant protein production and purification in an industry setting
- Proficiency with ÄKTA systems and UNICORN software, including the design and execution of protein purification methods
- Experience implementing protein characterization and binding assays, e.g. ELISA, BLI, and/or enzymatic activity
- Proficiency across multiple protein expression systems, such as bacterial, mammalian, insect, yeast, and/or cell-free platforms
- Experience generating proteins for high-resolution cryo-electron microscopy (cryo-EM) applications
- Demonstrated expertise in the purification and characterization of membrane proteins
- Experience with automation in a biochemistry context, such as automated protein purification or high-throughput assay development
- Experience with antibody or antibody fragment production and purification
Requirements
- Bachelor's degree in Biochemistry or a related field with a minimum of 2 years relevant experience in an academic or industry laboratory, or a MS degree in Biochemistry or a related field
- Hands-on experience in recombinant protein expression and purification, including transformation/transfection and affinity, ion-exchange, and size-exclusion chromatography
- Familiarity with protein construct design and analytical techniques including size-exclusion chromatography, dynamic light scattering, and thermostability assays
- Proven ability to rigorously document work in an ELN and maintain lab organization and inventories
- More than one year of experience with recombinant protein production and purification in an industry setting
- Proficiency with ÄKTA systems and UNICORN software
- Experience implementing protein characterization and binding assays such as ELISA, BLI, and/or enzymatic activity
- Proficiency across multiple protein expression systems such as bacterial, mammalian, insect, yeast, and/or cell-free platforms
- Experience generating proteins for high-resolution cryo-electron microscopy (cryo-EM) applications
- Demonstrated expertise in purification and characterization of membrane proteins
- Experience with automation in a biochemistry context
- Experience with antibody or antibody fragment production and purification
Benefits
- Healthcare coverage
- Annual incentive program
- Retirement benefits
Company overview
Flagship Pioneering is a pioneering biotechnology venture capital firm that specializes in conceiving, creating, and developing first-in-category life sciences companies. Founded in 2000 and headquartered in Cambridge, Massachusetts, the firm applies a unique hypothesis-driven innovation process to originate and foster scientific ventures with transformative potential for human health and sustainability. Flagship has originated over 100 scientific ventures since its inception, creating more than $30 billion in aggregate value across its portfolio. The firm's ecosystem includes notable companies such as Moderna Therapeutics, Denali Therapeutics, Evelo Biosciences, and Seres Therapeutics, among others. Flagship operates through a systematic entrepreneurship model that combines scientific creativity, technological ingenuity, and executive leadership to build platform companies capable of generating multiple breakthrough products. With over $3 billion in aggregate capital commitments, the firm invests primarily in therapeutics, health technologies, and sustainability sectors, working in partnership with academic institutions, pharmaceutical companies, and investment communities to advance groundbreaking science and innovation globally.