Research Associate II / Senior Research Associate, Protein Science
SystImmune
Summary
SystImmune is seeking a Research Associate II or Senior Research Associate to join the AIDD Protein Science Automation team in Bothell, WA. This is a newly created position established to benchmark and operate the company's antibody screening workflow. The Research Associate will provide the experimental capacity to run cell-free antibody and protein expression, purification, primary screening, and candidate confirmation, while generating reproducible protocols that can be transferred to automation.
Job description
This role is focused on wet-lab experimentation in protein science and assay development. The RA will contribute to setting up and building out the new automation wet lab. The successful candidate will independently execute reproducible cell-free protein synthesis, purification, and assay workflows with defined controls and SOPs. You will own routine screening batches, deliver consistent candidate data, and transfer validated methods to automation.
Responsibilities
Protein Expression and Purification
- Prepare DNA templates and run cell-free expression reactions for antibodies, antibody fragments, and other proteins
- Perform affinity or magnetic-bead purification, quantification, and protein quality assessment
Assay Execution and Screening
- Run AlphaLISA or ELISA primary screens and support BLI confirmation
- Own routine experimental setup, assay execution, data QC, repeat decisions, and protocol optimization within approved experimental plans
Method Development and Documentation
- Define controls, acceptance criteria, repeat rules, plate maps, and data-review templates
- Maintain reagents, experimental records, SOPs, and batch documentation
- Generate reproducible protocols and support the transfer of validated methods to automation
Lab Build-Out
- Contribute to setting up and building out the new automation wet lab and its robot-based workflows
Requirements
- Bachelor's or Master's degree in Molecular Biology, Biochemistry, or a related field
- Research Associate II requires bachelor's degree and 2+ years of industry experience
- Senior Research Associate requires bachelor's degree with 5+ years or master's degree with 3+ years of industry experience
- Hands-on recombinant protein expression and purification experience, preferably with antibodies or antibody fragments
- Experience with protein assays such as AlphaLISA, ELISA, BLI, SDS-PAGE, or comparable methods
- Strong experimental design, assay troubleshooting, data analysis, and documentation skills
- Completion of standard laboratory safety and data-integrity training upon hire. No external certification is required
Preferred
- Experience with cell-free protein synthesis (CFPS)
- Experience with magnetic-bead purification and AKTA chromatography
- Experience with Octet BLI instrumentation and BMG plate readers
- Experience with assay miniaturization
- Experience with automated liquid handlers or laboratory robotics
- Experience with barcode tracking or a laboratory information management system (LIMS)
Physical Requirements
Ability to stand and work at the bench or instrument platform for extended periods, and to occasionally lift or move laboratory equipment, reagents, and supplies.
Requirements
- Bachelor's or Master's degree in Molecular Biology, Biochemistry, or a related field
- Research Associate II requires bachelor's degree and 2+ years of industry experience
- Senior Research Associate requires bachelor's degree with 5+ years or master's degree with 3+ years of industry experience
- Hands-on recombinant protein expression and purification experience, preferably with antibodies or antibody fragments
- Experience with protein assays such as AlphaLISA, ELISA, BLI, SDS-PAGE, or comparable methods
- Strong experimental design, assay troubleshooting, data analysis, and documentation skills
- Completion of standard laboratory safety and data-integrity training upon hire. No external certification is required
- Experience with cell-free protein synthesis (CFPS)
- Experience with magnetic-bead purification and AKTA chromatography
- Experience with Octet BLI instrumentation and BMG plate readers
- Experience with assay miniaturization
- Experience with automated liquid handlers or laboratory robotics
- Experience with barcode tracking or a laboratory information management system (LIMS)
Benefits
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Short-Term Disability Insurance
- Long-Term Disability Insurance
- 401(k) With Company Match
- Paid Time Off
- Sick Leave
- Paid Holidays
Company overview
SystImmune is a biotechnology company specializing in immune system research and therapeutic development. The company focuses on advancing innovative approaches to modulate and harness the immune system for treating various diseases. With a name suggesting systemic immune system targeting, SystImmune likely engages in research areas such as immunotherapy, autoimmune disorders, cancer immunology, and infectious disease treatments. The company operates at the intersection of immunology and biotechnology, developing novel therapeutic candidates that aim to address unmet medical needs through immune system modulation. SystImmune's research efforts contribute to the growing field of immunotherapies, which have revolutionized treatment approaches for cancer and other immune-related conditions. The company represents the cutting edge of biotechnology research focused on understanding and manipulating immune responses for therapeutic benefit.