Research Associate, Process Development
Agilent Technologies
Summary
The candidate will be responsible for process chemistry and development activities that delivers milligram to gram quantities of active pharmaceutical ingredients (API) for oligonucleotide therapeutics. This includes assisting in developing synthetic routes, methods, and techniques in preparing, separating, purifying, analyzing, quantifying, and resolving oligonucleotide process components and objectives.
Job description
Essential duties and responsibilities include but are not limited to:
- Studying and implementing oligonucleotide project objectives and targets related to engineering and chemical requirements to better understand requirements. Additionally, they will be encouraged to study emerging trends in oligonucleotide analytical methods and synthesis development, review professional and technical publications, establish personal networks, and benchmark state-of-the-art practices.
- Execute process development experiments and activities. Documents analyses by completing experiment notebooks and records; implementing process chemistry applications and analyzing results of new oligonucleotide synthesis and purification methods and processes. This includes preparing process descriptions and writing technical reports to support internal technology transfer into manufacturing and preparation of client CMC submissions.
- Applies laboratory experience in chemistry and separations to issues of process optimization, scale-up and laboratory process transfer to mid and kilo scale GMP manufacturing while adhering to standard operating procedures (SOP's) and current good manufacturing practices to maintain compliance integrity (cGMP).
- Executes Design of Experiments (DOE) and Proven Acceptable Range (PAR) experiments to support design space understanding and process validation as they relate to oligonucleotide synthesis, process chromatography, and other purification and isolation techniques.
Qualifications
- Bachelors, Masters, or University Degree in chemistry, chemical engineering, or science. Equivalent or a combination of education and (a minimum of 2 years) experience in a pharmaceutical environment.
- Ability to work both independently and in a team setting on a variety of projects and use individual discretion to meet required time-sensitive objectives for assigned projects.
- Excellent math, documentation, communication and operational troubleshooting skills. General proficiency with tools, systems, and procedures required to accomplish the job.
- Proven knowledge of oligonucleotide synthesis, purification, ultrafiltration, conjugation, and lyophilization is advantageous.
- Knowledge of and skill in using computer software and hardware applications, including Microsoft products and the Internet.
Requirements
- Bachelors, Masters, or University Degree in chemistry, chemical engineering, or science
- Minimum of 2 years experience in a pharmaceutical environment
- Ability to work independently and in a team setting
- Excellent math, documentation, communication and operational troubleshooting skills
- General proficiency with tools, systems, and procedures
- Knowledge of oligonucleotide synthesis, purification, ultrafiltration, conjugation, and lyophilization is advantageous
- Knowledge of and skill in using computer software and hardware applications, including Microsoft products and the Internet
Benefits
- Bonus
- Stock
- Health Insurance
Company overview
Agilent Technologies is a global leader in life sciences, diagnostics, and applied markets, delivering innovative solutions that advance scientific discovery and improve quality of life. Founded in 1999 as a spin-off from Hewlett-Packard, the company has grown into a major player in analytical instrumentation and laboratory services. With approximately 18,000 employees worldwide and annual revenues exceeding $6.5 billion, Agilent provides a comprehensive portfolio of instruments, software, services, and consumables that serve laboratories across pharmaceutical, biotechnology, clinical diagnostics, environmental, food safety, and academic research sectors. The company's product offerings span chromatography systems, mass spectrometry, spectroscopy, cell analysis platforms, molecular diagnostics, and laboratory informatics solutions. Agilent's expertise extends beyond hardware to include comprehensive laboratory management services through its CrossLab division, which helps customers optimize laboratory operations, ensure regulatory compliance, and maximize research productivity. The company's commitment to innovation and customer support has made it a trusted partner for scientists and researchers worldwide who rely on Agilent's technologies to address complex analytical challenges and drive scientific breakthroughs.