Research Lab Technician I
Mass General Brigham
Summary
Under general supervision of the Principal Investigator and in accordance with established hospital policies and procedures, a position is open for an independent, self-motivated, full-time Technical Research Assistant in the Department of Pathology at Brigham and Women's Hospital. Our laboratory identifies blood-based biomarkers for early detection of complications of common pregnancy conditions (e.g., preeclampsia, premature rupture of membranes), and develops low-cost, simple diagnostics suited to low- and middle-income countries to help identify high-risk pregnancies.
Job description
The candidate will conduct research utilizing ultrasensitive single molecule array (Simoa) and Molecular On-bead Signal Amplification for Individual Counting (MOSAIC) assays to measure biomarkers that conventional methods cannot detect. Specific applications may include the characterization of biomarker concentrations in blood or other bio-fluids using assays developed using existing Simoa/MOSAIC technology or the development of new diagnostic techniques. A successful candidate will accurately prepare reagents, execute protein detection assays, and handle biological samples. The Technical Research Assistant will work as part of a research team, under general supervision, carrying out pre-outlined experiments and designing new experiments independently when needed.
- Independently performs routine and non-routine experiments that are moderate to complex. Experimental work may include preparing binding reagents and evaluating binding reagent viability in the assay platform, optimizing, validating, and modifying assays, screening biological samples, and preparing special materials.
- Operates the Simoa HD-X and MOSAIC instruments to analyze patient-derived blood, plasma, or serum from pregnancy cohorts.
- Calculates, transcribes, and analyzes data using moderate to advanced statistical techniques.
- Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication. Corresponds and communicates progress professionally with collaborators and scientific community.
- In collaboration with PI or Research Manager, establishes new and modifies existing research techniques.
- Coordinates schedule of tests and procedures. Documents experimental work accurately and in detail.
- Coordinates lab activities such as bio-safety trainings.
- Assists in the orientation and training of new staff.
- Orders supplies and maintains laboratory inventory.
- All other duties as assigned.
Requirements
- BA/BS in biological/physical science required
- At least one year of lab research experience in molecular biology, biochemistry, or similar is preferred
- Experience with nucleic acid analysis and/or protein biochemistry preferred
- ELISA
- Human subject research and/or BSL2 practices
- Programming experience (Python or R) for computational analysis of large biological datasets
- Programming of liquid handling robots
- Sound analytical and organizational skills
- High degree of computer literacy
- Good oral and written communication skills
- Ability to logically and effectively structure tasks and set priorities
- Ability to identify potential problems and trouble-shoot solutions
- Ability to accurately document, analyze, and interpret experimental data
- Ability to work both independently and collaboratively in a multidisciplinary research environment
- Strong attention to detail and ability to perform quantitative laboratory procedures accurately
Benefits
- Health insurance
- Career advancement opportunities
- Differentials
- Premiums
- Bonuses
- Recognition programs
Company overview
Mass General Brigham is one of the largest integrated healthcare delivery systems in the United States, formed through the merger of Massachusetts General Hospital and Brigham and Women's Hospital. Based in Boston, Massachusetts, this academic medical center system operates multiple hospitals, specialty facilities, and community health centers throughout New England. The organization is renowned for its world-class patient care, cutting-edge medical research, and comprehensive medical education programs. As a teaching affiliate of Harvard Medical School, Mass General Brigham trains the next generation of healthcare professionals while advancing medical science through groundbreaking research initiatives. The system provides a full continuum of healthcare services, from primary care and preventive medicine to complex specialty treatments and emergency services. With a focus on innovation and patient-centered care, Mass General Brigham consistently ranks among the top hospital systems in the nation for clinical excellence and research output.