Research Lab Technician I

Job Summary

Under general supervision of the Principal Investigator and in accordance with established hospital policies and procedures, provides technical support for research involving the development and application of ultrasensitive biomarker detection technologies. Performs laboratory experiments, documents experimental results, and analyzes data using appropriate statistical methods.

The laboratory develops and applies ultrasensitive protein detection technologies, including single molecule array (Simoa) and Molecular On-bead Signal Amplification for Individual Counting (MOSAIC), for biomarker detection and diagnostic applications. The candidate will develop, optimize, and perform ultrasensitive single- and multiplex protein assays to measure low-abundance biomarkers in human biofluids. Specific applications may include cancer biomarker detection and validation, early disease detection, treatment-response monitoring, and other diagnostic applications.

Responsibilities

• Independently performs routine and non-routine experiments of moderate to high complexity, including preparing reagents, conjugating and evaluating antibodies and other binding reagents, developing and optimizing Simoa and MOSAIC assays, generating calibration curves, performing single- and multiplex biomarker measurements in human biofluids, evaluating assay performance, and troubleshooting experimental procedures.
• Calculates, transcribes, and analyzes data using moderate to advanced statistical techniques.
• Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication. Corresponds and communicates progress professionally with collaborators and scientific community.
• In collaboration with PI or Research Manager, establishes new and modifies existing research techniques.
• Coordinates schedule of tests and procedures. Documents experimental work accurately and in detail.
• Coordinates lab activities such as bio-safety trainings.
• Assists in the orientation and training of new staff.
• Ordering and inventory of laboratory supplies.

Qualifications

Education: BA/BS in biological, chemical, physical, or related science required. Prior laboratory research experience preferred but not essential. Experience in lieu of a degree may be accepted.

Experience: Prior laboratory experience, either through academic coursework, internships, or employment, 1-2 years preferred.

Knowledge, Skills and Abilities

• Sound analytical and organizational skills
• High degree of computer literacy
• Good oral and written communication skills
• Ability to logically and effectively structure tasks and set priorities
• Ability to identify potential problems and trouble-shoot solutions
• Ability to accurately document, analyze, and interpret experimental data
• Ability to work both independently and collaboratively in a multidisciplinary research environment
• Strong attention to detail and ability to perform quantitative laboratory procedures accurately