Summary

The Research Technician is a full-time, on-site role based in Aurora, CO. This role supports preclinical and translational research activities related to the development and optimization of cell therapy programs. Day-to-day responsibilities include performing experiments involving cell engineering of human T cells, in vitro T cell functional assays, and in vivo tumor control experiments. The Research Technician will assist with experimental design, collect and record data in electronic systems, and contribute to data analysis and interpretation. Additional duties include equipment maintenance, inventory management, adherence to safety and biosafety guidelines, and close collaboration with cross-functional team members. A successful candidate will bring strong technical skills and scientific curiosity.

Job description

Role Description

The Research Technician is a full-time, on-site role based in Aurora, CO. This role supports preclinical and translational research activities related to the development and optimization of cell therapy programs. Day-to-day responsibilities include performing experiments involving cell engineering of human T cells, in vitro T cell functional assays, and in vivo tumor control experiments. The Research Technician will assist with experimental design, collect and record data in electronic systems, and contribute to data analysis and interpretation. Additional duties include equipment maintenance, inventory management, adherence to safety and biosafety guidelines, and close collaboration with cross-functional team members. A successful candidate will bring strong technical skills and scientific curiosity.

Responsibilities

Execute experiments using primary human T cells and other immune cell populations, including isolation, activation, genetic modification, expansion, cryopreservation, and recovery.
Perform T cell functional assays to evaluate activation, proliferation, cytokine production, cytotoxicity, persistence, and other relevant phenotypes.
Optimize and troubleshoot flow cytometry-based assays, including immunophenotyping and intracellular cytokine staining.
Execute mouse studies to evaluate safety and efficacy of cell therapy candidates. Perform tumor engraftment, cell therapy administration, animal monitoring, tissue collection, and downstream sample processing.
Communicate results clearly through experimental summaries, figures, presentations, and reports.
Maintain laboratory readiness, including cell cultures, reagents, equipment, and experimental materials.

Requirements

Bachelor's or Master's degree in biology, immunology, or a related field
Strong research and analytical skills, including ability to follow experimental protocols, troubleshoot issues, and interpret scientific data
Core laboratory skills such as pipetting, solution preparation, use of common lab equipment, and strict adherence to safety, quality, and documentation standards
Hands-on experience with tissue culture techniques, including aseptic handling, cell expansion, and monitoring of cell health and viability
Experience handling human T cells is preferred
Competence in data analysis, including organizing data, using statistical methods/software, and clearly documenting and presenting findings
Strong understanding of experimental controls and interpretation of biological data
Ability to work collaboratively in a team-based environment, follow detailed instructions, manage time effectively, and maintain meticulous records
Familiarity with oncology, immunology, or cell therapy research is beneficial
Prior experience in industry or regulated laboratory settings is a plus
Experience with T cell engineering, viral transduction, cell manufacturing workflows, tumor implantation, tumor monitoring, and tissue collection are beneficial

Benefits

Paid Time Off
401(k)

Company overview

TrAMPoline Pharma, Inc. is a cancer-focused, clinical-stage biotechnology company headquartered in Aurora, Colorado, developing personalized cell-based immunotherapies for solid tumor cancers, which account for roughly 90% of all cancers. The company's lead therapeutic candidate, MightyTIL™, leverages its proprietary coR8:Amp™ platform to produce gene-engineered Tumor Infiltrating Lymphocytes (TILs) with enhanced T-cell receptor binding and signaling. This approach drives stronger activation and killing of cancer cells, improved persistence, and reduced T-cell exhaustion compared with unmodified TIL therapies. TrAMPoline was co-founded by Eduardo Davila, PhD, who serves as Chief Scientific Officer, and is led by President and Acting CEO Richard Duke, PhD. The company holds an exclusive license with the University of Maryland, Baltimore (established in 2019) and has received NIH National Cancer Institute SBIR/STTR funding. It is advancing MightyTIL™ toward a Phase 1 clinical trial in partnership with the Gates Biomanufacturing Facility at the University of Colorado Anschutz Medical Campus.