Scientific Associate Director, Human Disease Biology, Inflammation Research

Key Responsibilities

• Develop and execute a disease-focused discovery strategy leveraging multi-omic and human data to deepen mechanistic understanding of respiratory, dermatologic, or rheumatologic diseases.
• Continuous adoption of technology, AI/computation and innovation to improve efficiency and quality of work.
• Integration of systems immunology, multi-omics, AI-enabled biology, and human disease research to bring unique insights and innovative approaches to Amgen's discovery efforts.
• Lead cross-functional scientific initiatives that integrate human genetics, single-cell biology, spatial biology, proteomics, and computational analyses to identify and validate first/best-in-class therapeutic targets, patient segments and biomarker strategies.
• Drive generation and interpretation of multimodal datasets and translate findings into actionable hypotheses for target discovery and program prioritization/advancement.
• Partner closely with computational biology, translational sciences, human genetics, pathology, and disease-area biology teams to build integrated disease models and prioritize therapeutic opportunities.
• Serve as a scientific leader for disease-focused discovery efforts and provide expertise in human tissue biology, disease pathogenesis, and emerging technologies.
• Design and oversee internal and external collaborations with academic investigators, clinical researchers, consortia, and technology partners.
• Contribute to advancement of programs through target validation, indication selection, biomarker identification, and patient stratification strategies.
• Mentor scientists and foster rigorous, collaborative, and innovative scientific practices across project teams.
• Leads multiple cross-functional projects and scientific initiatives focused on disease understanding and target discovery.
• Influences the direction of several discovery programs through generation of disease insights and translational hypotheses.
• Serves as a recognized expert in disease biology and multi-omic analysis within the department.
• Contributes to departmental strategy related to human biology, disease understanding, and technology deployment.
• Builds productive collaborations across research functions and external scientific communities.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of relevant scientific experience OR Master’s degree and 7 years of relevant scientific experience OR Bachelor’s degree and 9 years of relevant scientific experience

Preferred Qualifications

• Significant experience in both academic research and biopharmaceutical drug discovery.
• Experience integrating human genetics, transcriptomics, proteomics, single-cell, spatial, imaging, and clinical datasets to generate actionable biological insights that inform target validation, biomarker strategies, patient stratification approaches, and drug discovery programs.
• Strong understanding of the drug discovery and development process, including target identification, validation, translational strategy, and preclinical development.
• Demonstrated ability to lead matrixed teams and build productive collaborations across scientific disciplines.
• Record of scientific achievement as evidenced by high-impact publications, presentations, patents, external collaborations, or contributions to advancing therapeutic programs.
• Curiosity-driven scientist with a passion for understanding human disease biology and leveraging emerging technologies to accelerate discovery.
• Excellent communication skills and ability to influence scientific strategy across diverse stakeholders.